PURPOSE To evaluate the value of magnetoencephalography (MEG) source localization in localization of epileptic activities and predicting surgical outcome in frontal lobe epilepsies (FLE). METHODS Forty-six patients with presurgical MEG evaluation and intractable FLE surgery (28 male patients) were analyzed retrospectively with a mean follow-up of 5 years. Dipole analysis was performed for MEG...

The topic of this presentation is the investigation of the epileptic human brain as a nonlinear system that undergoes a phase transition (epileptic seizure). The estimated values of the largest Lyapunov exponent L over time indicated a more chaotic state postictally than ictally or preictally. The start of a seizure corresponds to a simultaneous drop in the values of L at the focal electrode si...

Although refractory epileptic patients suffer from uncontrolled seizures, their quality of life (QoL) may be improved if the seizure can be predicted in advance. In the preictal period, the excessive neuronal activity of epilepsy affects the autonomic nervous system. Since the fluctuation of the R-R interval (RRI) of an electrocardiogram (ECG), called heart rate variability (HRV), reflects the ...

The authors reexamine the correlation integral and the related correlation dimension in the context of EEG analysis with application to seizure prediction. They identify dependencies of the correlation integral and the correlation dimension on frequency and amplitude of the signal, which may result in a reinterpretation of the dynamic importance of these measures and may cast doubts on their pr...

We compare dynamical properties of brain electrical activity from different recording regions and from different physiological and pathological brain states. Using the nonlinear prediction error and an estimate of an effective correlation dimension in combination with the method of iterative amplitude adjusted surrogate data, we analyze sets of electroencephalographic (EEG) time series: surface...

Disturbances in cognitive function, particularly memory, are a common complaint of patients with epilepsy. Factors contributing to cognitive dysfunction are the type of epilepsy, type and frequency of seizures, anti-epileptic drugs and the location of underlying brain lesions. Whilst a great deal of attention has been paid to permanent cognitive impairment, the nature and underlying mechanisms ...

Preliminary results from animal and clinical studies demonstrate that electrical stimulation of brain structures can reduce seizure frequency in patients with refractory epilepsy. Since most researchers derive stimulation parameters by trial and error, it is unclear what stimulation frequency, amplitude and duration constitutes a set of optimal stimulation parameters for aborting seizure activi...

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The generalized differential quadrature (GDQ) method is used to obtain the computational results of two-layer cross-ply laminated shell under rapid uniform heat induced vibration. In the thermally insulated vibration analyses of a laminated shell, the sudden uniform heat input over its lower surface only and temperature load is linear of axial coordinate. The GDQ method provides a method for ca...

An index observation where a dog was trained to alert to, as well as respond to, human tonic-clonic seizures led to further research and refinement of training techniques. This was followed by anecdotal reports of pet dogs spontaneously anticipating human epileptic seizures. An industry has since developed training Seizure-Alert Dogs (SADs) to give humans warnings of their seizures. In some cas...