Background: Despite introduction of modern antiepileptic drugs, 30% of epileptic patients are still drug resistant. Remarkable three-dimensional spatial structure of AdCA, yet the simplicity of the molecule, makes AdCA a promising lead compound. Methods: Sedative/motor impairment and 24-h mortality rate of AdCA were determined in mice. Impact of AdCA on (1) threshold and occurrence of clonic se...

OBJECTIVE To analyze seizure control and treatment in pregnant women with epilepsy. METHODS Seizure control and treatment were recorded prospectively in 1,956 pregnancies of 1,882 women with epilepsy participating in EURAP, an international antiepileptic drugs (AEDs) and pregnancy registry. RESULTS Of all cases, 58.3% were seizure-free throughout pregnancy. Occurrence of any seizures was as...

Eclampsia is defined in the obstetrical literature as the occurrence of unexplained seizure during pregnancy in a woman with preeclampsia.1,2 In the Western world, the incidence of eclampsia is ∼1 per 2000 to 1 per 3000 pregnancies3–5, but the incidence is 10-fold higher in tertiary referral centers and undeveloped countries where there is poor prenatal care, and in multi-fetal gestations.6,7 N...

The aims of the study were to characterize the magnitude of clearance changes during pregnancy for multiple antiepileptic drugs (AEDs) and to assess seizure frequency and factors increasing seizure risk in pregnant women with epilepsy. A retrospective analysis was performed for 115 pregnancies in 95 women with epilepsy followed at the Emory Epilepsy Center between 1999 and 2012. Antiepileptic d...

Due to the unpredictable interruptions within functions of human brain, disturbance occurs and it affects behavior is equally laid low with frequent occurrence termed as seizures. Therefore, proposed system detects seizure using machine learning algorithms. The electroencephalogram (EEG) contains information brain detect seizure. objective evaluate performance classifiers K-nearest neighbors (K...

Propofol is a popular agent for induction and maintenance of anaesthesia, as well as an excellent sedative agent widely used in ambulatory anaesthesia. Although involuntary movements due to propofol are well known, the occurrence of propofol-related seizure activity in patients with no previous history of epilepsy is less well highlighted. These seizures may occur at all stages of anaesthesia: ...

Frontal lobe epilepsy (FLE) surgery is the second most common surgery performed to treat pharmacoresistant epilepsy. Yet, little is known about long-term seizure outcome following frontal lobectomy. The aim of this study is to investigate the trends in longitudinal outcome and identify potential prognostic indicators in a cohort of FLE patients investigated using modern diagnostic techniques. W...