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Menopause is the physiological process of cessation of normal menstruation occurring in the fifth decade of life in women. This leads to certain hormonal variations which results in few clinical systemic manifestations along with oral symptoms. The main oral symptoms include oral dryness, mucosal lesions such as lichen planus, benign pemphigoid, Sjogren syndrome and burning mouth syndrome with ...

Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by the triad of congenital ichthyosis, spastic diplegia or quadriplegia, and mental retardation. Herein we report a 2-year-old male child with SLS, asthma, and recurrent pneumonia. SLS was confirmed by a molecular genetics study that reveal...

This work has its origin in the Fellowship thesis for the Royal College of Veterinary Surgeons of one of us. We would like to thank the thesis supervisor Peter Lee for his invariably prompt and helpful criticisms of this work. We would like to thank Niclas Sjogren (latterly of AstraZeneca Statistics Department) for the fruitful discussions of the ideas from which this work came. Mr. Christopher...

Walls & Negroni (1966) reported the isolation in tissue culture of a transformed but non-malignant clone of cells from a polyoma virus-induced fibrosarcoma of C3H Bi mice. These cells, when inoculated into C.AH Bi mice, did not grow as tumours but immunized the animals against malignant cells derived from the same fibrosarcoma. Furthermore the serum from mice thus immunized prevents the growth ...

BACKGROUND Clinical needs often dictate testing for several autoantibodies in a single patient with evidence of autoimmune disease. We developed a microarray containing 15 autoantigens for the detection of autoantibodies in rheumatoid autoimmune diseases. METHODS We synthesized recombinant centromere protein B, cytokeratin 19, SSA 52-kDa antigen, SSA 60-kDa antigen, SSB antigen, and Jo-1 anti...