Secondary bacterial pneumonia leads to increased morbidity and mortality from influenza virus infections. What causes this increased susceptibility, however, is not well defined. Host defense from infection relies not only on immune resistance mechanisms but also on the ability to tolerate a given level of pathogen burden. Failure of either resistance or tolerance can contribute to disease seve...

PURPOSE OF REVIEW Bacterial sepsis is a leading cause of death in the United States, accounting for over 200,000 fatalities annually. Approximately half of bacterial sepsis cases occur following acute respiratory infections, and the lungs are the most common organs to fail. Notably, outbreaks of respiratory viral infections are associated with an increased incidence or severity of bacterial co-...

Avian pneumovirus (APV) causes turkey rhinotracheitis (TRT) and swollen head syndrome (SHS) of chickens, which is usually accompanied by secondary bacterial infections that increase mortality. In Iran, some serological studies indicated that APV infection is endemic in commercial poultry industry. In this study we diagnosed APV genome molecularly in suspected broiler flock (4 weeks) in Iran and...

Dermatophilosis is a bacterial skin infection and wet conditions like, raining and dipping predispose sheep to it. A great economic loss can be caused by this disease because of its effect on the quality of wool. In Iran (near Saveh), there was an outbreak of the disease in a herd and the clinical manifestation was different from that of typical dermatophilosis. Diffuse wide alopecic area accom...

Abstract Nontypeable Haemophilus influenzae(NTHi) is one of the most common bacteria that cause secondary bacterial pneumonia following influenza A virus (IAV) infection, leading to hospitalization and death associated with IAV infection worldwide. Current efforts develop vaccines against NTHi focus on inducing antibodies but are hindered by antigenic diversity among strains. Therefore, we inte...

Background: Herpes simplex virus type 1 is one of the most common viruses among human population. Studies demonstrate the essential role of cell mediated immunity, especially CD8+ T cells, in prevention and clearance of HSV1. Objective: It is of great importance to improve our knowledge about the kinetics of CTL responses to primary and secondary HSV-1 infection. Methods: Using a sensitive tech...