introduction: many of the diseases of adulthood are originated from the intrauterine conditions during fetal life. because of the importance of thyroid hormones in growth and development of the fetus, the effects of maternal hypothyroidism on carbohydrate metabolism in adulthood was investigated. methods: pregnant rats were divided into the fetal hypothyroidism (fh) and the control (c) groups. ...

Background: Maternal mRNA degradation is a selective process that occurs in waves corresponding to important developmental transitions such as resumption of meiosis, fertilization and zygotic genome activation. It has been demonstrated that the number, position, and combination of 3 UTR cis-acting elements interacting with trans-acting protein factors regulate translation and mRNA stability. Ou...

In vitro, animal model and anecdotal clinical evidence suggests that tuberculosis (TB) is not a monomorphic disease, that host response to TB protean with multiple distinct molecular pathways pathologies (endotypes). We used unbiased clustering identify separate endotypes distinctive gene expression patterns different outcomes. A discovery cohort included 443 patients 527 asymptomatic controls ...

Background and aim: Diabetes mellitus is a metabolic disease with multiple complications. Skin tag is a pedunculated papule, which is more common in women and has been suggested as a cutaneous marker of diabetes mellitus. The aim of this study was to determine the frequency of diabetes mellitus in patients with skin tags.Materials and methods: This descriptive study was...

The purpose of the present study was to investigate the context of lipid metabolism research in physical activity, lipolysis, lipolysis hormone regulation and the fate of lipolysis products in exercise, fatty acid transporters, some genes involved in lipid metabolism, effect of resistance activity on lipolysis, adaptations of adipose tissue due to physical activity, lipoproteins and apoproteins...

Effective supplementation with folate, which prevents neural tube defect (NTD) occurrence, and high homocysteine levels in the blood of NTD children's mothers suggest that genes involved in folate and homocysteine metabolism can be involved in NTD aetiology. Genes encoding methylenetetrahydrofolate reductase (MTHFR) or methylenetetrahydrofolate dehydrogenase (MTHFD) belong to the first group. G...

AIMS: 4-Iodo-2,5-dimethoxyamphetamine (DOI), 4-bromo-2,5-dimethoxyamphetamine (DOB), 4-bromo2,5-dimethoxymethamphetamine (MDOB), and 2,4,5-trimethoxyamphetamine (TMA-2) are designer drugs which have appeared on the illicit drug market. Meanwhile, DOB and TMA-2 have been scheduled in the German Controlled Substances Act. Because of the various possibilities of interactions between different drug...

barley (hordeum vulgare l.) is a model plant, as genetic and physiological studies are concerned. abiotic stresses such as drought adversely affect the growth of plants. the objective of this experiment was to identify the responsive genes to osmotic stress, using macroarray (covering 13050 genes). rna was extracted from 5 barley genotypes in stress as well as in normal conditions at 3 times of...

Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Division of Internal Medicine, Rambam Health Care Campus and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel Institute of Endocrinology, Diabete...