BACKGROUND Plasma phospholipid transfer protein (PLTP) transfers lipids between donors and acceptors (e.g., from HDL to VLDL) and modulates lipoprotein composition, size, and levels. No study has reported an assessment of the effects of PLTP on blood clotting reactions, such as reflected in thrombin generation assays, or on the association of venous thrombosis (VTE) risk with PLTP activity. M...

Coagulation factor XII (FXII) assists in thrombus formation and may be important in cardiovascular and inflammatory mediated diseases. We have identified a naturally occurring mutation in the feline FXII gene that encodes a catalytically inactive mutant protein. We sequenced the genomic loci encoding factor XII in wild type cats and analyzed mRNA sequences encoding FXII in wild type and FXII de...

Metal price is one of the most important parameters in the calculation of cut- off grade. The cut- off grade has the main role in determination of mine layout. Mine layout actuates mineable reserve, mine life and economic profitability. Not considering the uncertainty in metal prices can lead to a non-optimal layout. In this paper optimum underground mine layout is determined by expected utilit...

In Hilary term 2014, members of congregation and all University staff were invited to respond to a consultation about possible changes to Statute XII, the statute that governs matters such as discipline, dismissal and grievance procedures for all University staff of grade 6 and above. the consultation document and the responses to it can be accessed from www.ox.ac.uk/ staff/consultations/statut...

1Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, Direction des Sciences du Vivant-Commissariat à l’Energie Atomique, Orsay, France; 2Institut National pour la Santé et la Recherche Médicale, Unité 400, Université de Médecine, Créteil, France; 3Fédération de Cardiologie, Centre Hospitalo-Universitaire Henri Mondor-Université Paris XII, Créteil, France; and 4Service de Méd...

........................................................................................................................... viii Abbreviations and Definitions........................................................................................... ix Publications ....................................................................................................................... xi Prelimin...

The annexins are a structurally related family of Ca2+ and phospholipid binding proteins whose function has not been clearly defined. Further investigations of annexin function may be enhanced by studying simpler organisms that express fewer annexin gene products. We previously characterized annexin XII from the freshwater cnidarian Hydra vulgaris (Schlaepfer, D. D., D. A. Fisher, M. E. Brandt,...

A a common chronic illness among children and youth, affects one school-aged child in 11, or two to three students in a class of 30. Asthma accounts for 14 million lost school days each year. Students with asthma miss instruction while in the health room and may not be fully alert due to lack of sleep from night­ time asthma symptoms. Schools often lose funding for student absences. Schools are...