Injuries of the sciatic nerve are common causes of pain and limitation in the lower limbs. Due to its particular anatomy and its long course, the sciatic nerve is often involved in diseases of the pelvis or leg. In recent years, magnetic resonance neurography has become established as an important tool for the study of peripheral nerves and can be widely applied to the study of the sciatic nerv...

We hypothesized that a chemically extracted acellular allogeneic nerve graft used in combination with bone marrow mesenchymal stem cell transplantation would be an effective treatment for long-segment sciatic nerve defects. To test this, we established rabbit models of 30 mm sciatic nerve defects, and treated them using either an autograft or a chemically decellularized allogeneic nerve graft w...

BACKGROUND Initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. The purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves. METHODS NMRI mice (n = 200) with injured left paw, caused by crushing their sciatic nerves, were randomly sele...

the purpose of this experimental study was to evaluate the effect of chicken amniotic fluid (af) on a cross section of rat sciatic nerves. thirty adult male sprague-dawley rats weighing 275 to 300 g, were randomized into three groups treated with (1) amniotic fluid or af (n=10), (2) normal saline or ns (n=10), and (3) sham surgery (n=10). the af was aspirated from the amniotic cavity of incubat...

BACKGROUND Walking track analysis which has been widely used to examine the recovery of gait functions in rats with sciatic nerve injury. PURPOSE The present study was aimed to objectively analyze and quantify the degree of functional recovery in locomotor behavior of rats after inflicting sciatic nerve crush injury. METHODS Wistar rats trained on various runways, viz., narrow beam, grid an...