Highlights:1. Schizophrenic patients have cognitive dysfunction.2. Meloxicam, as an adjuvant therapy, can improve function in schizophrenic patients. AbstractIntroduction: Schizophrenia is a chronic psychotic disorder triggered by genetic and environmental factors such inflammatory response. The response increases with decline. Meloxicam non-steroidal anti-inflammatory drug (NSAID) group Cyclo-...

BACKGROUND No study outside the UK has examined the diagnostic stability of psychotic disorders in a population-based sample. AIMS To determine diagnostic stability in a Dutch population-based psychosis incidence cohort, to examine the frequencies of diagnostic shifts to and from schizophrenic disorders and to report the revised relative risks of schizophrenic disorders for immigrants. METH...

BACKGROUND Functional neuroimaging experiments have implicated prefrontal cortex (PFC) in memory processes. Several studies of schizophrenic patients have shown failure of activation in the dorsolateral region of PFC (DLPFC). We used a graded memory challenge to characterize functional neuroanatomical differences between schizophrenic and control subjects. The graded manipulation of task demand...

We attempted to determine whether schizophrenic patients can improve their performance on an abstract reasoning task through experience, and to ascertain how the degree of learning compares with brain-damaged patients and patient controls. Two hundred and two schizophrenic patients, 179 brain-damaged patients and 229 patient controls were compared with regard to their improvement on Subtest 6 r...

BACKGROUND Prior research has shown reductions of the N1, N2, and P300 auditory event-related potential (ERP) components in schizophrenic patients. Most studies have shown a greater P300 reduction in left versus right temporal leads in schizophrenic patients. These studies were done with sparse electrode arrays, covering restricted areas of the head, thus providing an incomplete representation ...

Enhancement of semantic priming effects (hyperpriming) has been well documented in schizophrenic patients (Minzenberg et al. 2002 ). In a previous study, we demonstrated that hyperpriming was related to a more pronounced requirement to inhibit unrelated information ( ). On the other hand, several authors have suggested that hyperpriming could reflect enhanced spreading of semantic Lecardeur et ...

Patients with schizophrenia routinely fail to perform affect recognition tasks as accurately as healthy controls. The investigation of performance-related changes in cerebral activation in healthy subjects may facilitate the understanding of adaptation processes to different levels of difficulty and help to interpret the activation changes found in schizophrenic patients. Nine first hospitalize...

OBJECTIVE Auditory processing difficulties have been reported in schizophrenia. This study explores peripheral auditory function in patients with schizophrenia in whom certain early disturbances of auditory message filtering have been found and may be associated with certain abnormalities which are particularly localised in the left temporal lobe. METHODS Otoacoustic emissions, including clic...

BACKGROUND Not only the prevalence, but also the progress of metabolic abnormalities in schizophrenic patients is of importance for treatment planning and policy making. However, there have been very few prospective studies of metabolic disturbance in schizophrenic patients. This study aimed to assess the progress of metabolic abnormalities in Thai individuals with schizophrenia by estimating t...

OBJECTIVES This study is the first to use magnetisation transfer imaging (MTI), a technique sensitive to myelin and axonal abnormalities, to investigate the white matter in vivo in patients with schizophrenia. METHODS MTI was performed in 25 schizophrenic patients and 30 healthy controls. A region of interest (ROI) approach was used to obtain magnetisation transfer ratios (MTRs) in several re...