Abstract Background Schizophrenia, a chronic mental disorder, has been recognized as one of the heritable diseases with an increased level dopamine neurotransmitter. Monoamine oxidase A (MAOA) plays vital role in catabolism dopamine. It is mitochondrial enzyme which encoded by MAOA gene located on X chromosome. The aim this study was to detect potential biomarker order diagnose schizophrenia. H...

objective: to study the effects of a high dose alpha-tocopherol on serum total cholesterol (tc), triglyceride (tg), and the high density lipoprotein (hdl) levels of patients with schizophrenia receiving olanzapine. method: thirty six adults diagnosed with schizophrenia based on dsm-iv who were taking olanzapine for a minimum of thirty days entered this eight-week, double blind, placebo-controll...

schizophrenia and various neurological disorders have some signs and symptoms. visual hallucinations are one of such disorders. the related studies in some diseases for example parkinson disease and lewy body dementia indicate that acetylcholine (ach) plays a significant role in neuropsychiatric manifestation and its association with visual hallucination; therefore, visual hallucinations occur ...

background: patients with schizophrenia can experience a deteriorated performance in many of the skills needed in daily life, the workplace, the family circle, or in social interactions.objective: this definitive study used comparison to evaluate the functionality, treatment compliance to therapy, and styles of coping with stress of schizophrenic patients who work and are members of an associat...

the molecular mechanisms of the fact that more than 50% of the individuals with the same genetic make up (e.g. identical twins in schizophrenia) do not show the same psychiatric phenotype remained undefined in psychiatry. this along with the failure to find responsible genes with major effects in psychiatric disorders and lack of consistency of genetic association studies led to the current una...

linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (scz) and bipolar mood disorder (bpd) are common. numerous evidences for linkage of two diseases on chromosome 22 have been found. these findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. in the present case-control study, association ...

Abstract Objective: The effect of metformin on weight changes and some metabolic parameters in patients with schizophrenia and schizoaffective disorder was investigated in this study. Methods:  This study, performed during 2018-2019, was a randomized, double-blind, controlled clinical trial. A total of 66 obese patients (BMI≥27) with schizophrenia and schizoaffective disorder, hospitalized in...

Introduction: Schizophrenia is a chronic heterogenic neurodevelopment disorder. Many genes interfere in the development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1, which were evaluated in this study, were previously reported to be associated with Schizophrenia. The NrCAM contributes to creating cognitive deficiencies through the CAM’s signaling pathway. PRODH plays a vital role in cr...