نتایج جستجو برای: scale inhibitors

تعداد نتایج: 762426  

Journal: :European Heart Journal 2022

Abstract Background and purpose Treatment effects from the large cardiovascular outcome trials (CVOTs) in diabetes are almost exclusively communicated as hazard ratios, although reporting guidelines recommend to report treatment also on an absolute scale, e.g. numbers needed treat (NNT). We aimed analyze NNT CVOTs of novel oral antidiabetic drugs comparing dipeptidyl peptidase-4 (DPP-4) inhibit...

Journal: :iranian journal of allergy, asthma and immunology 0
hassan mansouri torghabeh aliakbar pourfathollah mahmood mahmoodian shooshtari zahra rezaie yazdi

many investigations have proved relations between abo blood groups with some diseases and factor viii and von willebrand level in plasma. in this study we investigated a relation between abo blood groups and factor viii and ix inhibitors in 102 patients with haemophilia a and 48 patients with haemophilia b. the assay of inhibitor was done by bethesda method. there were no relation between abo b...

Atta-ur-Rahaman Zaheer-ul-Haq A Khalid F Feroz M Iqbal Choudhary S Anjum

The genus Sarcococca is widely distributed in South-East Asia and it comprises 14 species. The genus is traditionally used for gastrointestinal ulcers, infections, pain and in rheumatic fevers. Recently, our group has derived a comprehensive SAR relationship picture for a new series of natural cholinesterase inhibitors isolated from Sarcococca saligna (syn. S. pruniformis, Buxaceae). The fracti...

Several nonpeptide small molecules were designed as potential inhibitors of HIV protease and their structures were constructed by computer-aided molecular modeling and docked iwo the active site of HIV protease. Models of the complexes of inhibitors and the HIV protease were refined using nonbonded and H-bonding terms. The refined energy of selected complexes showed that the designed inhib...

Journal: :journal of sciences islamic republic of iran 0

several nonpeptide small molecules were designed as potential inhibitors of hiv protease and their structures were constructed by computer-aided molecular modeling and docked iwo the active site of hiv protease. models of the complexes of inhibitors and the hiv protease were refined using nonbonded and h-bonding terms. the refined energy of selected complexes showed that the designed inhibitors...

Journal: :the iranian journal of pharmaceutical research 0
jamal shamsara pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, iran ahamad shahir-sadr bioinformatics research center, sabzevar university of medical sciences, school of medicine, sabzevar, iran.

design of selective cyclooxygenase-2 (cox-2) inhibitors is still a challenging task because of active site similarities between cox isoenzymes. to help with this issue, we tried to generate a 3d-qsar (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of cox-2 active sites. compounds in a series of resveratrol derivatives inhibitors with ...

2016
Gianfranco Battistuzzi Giuseppe Giannini

ABSTRACT BACKGROUND In the expanding field of anticancer drugs, HDAC inhibitors are playing an increasingly important role. To date, four/five HDAC inhibitors have been approved by FDA. All these compounds fit the widely accepted HDAC inhibitors pharmacophore model characterized by a cap group, a linker chain and a zinc binding group (ZBG), able to bind the Zn2+ ion in a pocket of the HDAC acti...

Journal: :asia pacific journal of medical toxicology 0
jalal pourahmad department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

by discovering how chemical compounds/xenobiotics cytotoxicity is affected when their metabolic pathways are inhibited or activated, the metabolic pathways that activate versus detoxify chemical compound can be identified. reactive metabolites contributing to cytotoxicity can also be identified. in this lecture, the pretreatment of inhibitors and activators of xenobiotic metabolizing enzymes as...

Journal: :Asian Journal of Pharmaceutical and Clinical Research 2021

Objective: Depression is one of the most common mood disorders. Patients with major depressive disorder (MDD) usually present alterations in various cognitive functions. Several cost-effective interventions have shown favorable recovery and positive outcomes care management depression. The objective study was to compare effect fluoxetine (selective serotonin reuptake inhibitors), venlafaxine (s...

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

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