نتایج جستجو برای: sars cov 2

تعداد نتایج: 2534203  

Journal: :Journal of virology 2010
Jincun Zhao Jingxian Zhao Stanley Perlman

A dysregulated innate immune response and exuberant cytokine/chemokine expression are believed to be critical factors in the pathogenesis of severe acute respiratory syndrome (SARS), caused by a coronavirus (SARS-CoV). However, we recently showed that inefficient immune activation and a poor virus-specific T cell response underlie severe disease in SARS-CoV-infected mice. Here, we extend these ...

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Journal: :Journal of immunology 2008
Chris Ka-fai Li Hao Wu Huiping Yan Shiwu Ma Lili Wang Mingxia Zhang Xiaoping Tang Nigel J Temperton Robin A Weiss Jason M Brenchley Daniel C Douek Juthathip Mongkolsapaya Bac-Hai Tran Chen-lung Steve Lin Gavin R Screaton Jin-lin Hou Andrew J McMichael Xiao-Ning Xu

Effective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs. We conducted a cohort study examining multiple parameters of immune responses to SARS-CoV infection, aiming to identify the immune correlates of protection. We used a matrix of overlapping pep...

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Journal: :Virology 2005
Himani Bisht Anjeanette Roberts Leatrice Vogel Kanta Subbarao Bernard Moss

A secreted, glycosylated polypeptide containing amino acids 14 to 762 of the SARS coronavirus (SARS-CoV) spike protein and a polyhistidine tag was expressed in recombinant baculovirus-infected insect cells. Mice received the affinity-purified protein with either a saponin (QS21) or a Ribi (MPL + TDM) adjuvant subcutaneously and were challenged intranasally with SARS-CoV. Both regimens induced b...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Zhongyu Zhu Samitabh Chakraborti Yuxian He Anjeanette Roberts Tim Sheahan Xiaodong Xiao Lisa E Hensley Ponraj Prabakaran Barry Rockx Igor A Sidorov Davide Corti Leatrice Vogel Yang Feng Jae-Ouk Kim Lin-Fa Wang Ralph Baric Antonio Lanzavecchia Kristopher M Curtis Gary J Nabel Kanta Subbarao Shibo Jiang Dimiter S Dimitrov

The severe acute respiratory syndrome coronavirus (SARS-CoV) caused a worldwide epidemic in late 2002/early 2003 and a second outbreak in the winter of 2003/2004 by an independent animal-to-human transmission. The GD03 strain, which was isolated from an index patient of the second outbreak, was reported to resist neutralization by the human monoclonal antibodies (hmAbs) 80R and S3.1, which can ...

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Journal: مجله علمی دانشگاه علوم پزشکی قزوین 2021
Ahmad Jamalizadeh, Aliakbar Yousefi-Ahmadipour, Athareh Soresrafil, Fatemeh Mohseni Moghadam, Kazem Mashayekhi, Mahnaz Tashakori, Maryam Hadavi, Mohsen Nejad-Ghaderi,

Background: Healthcare workers (HCWs) have a high risk of SARS-CoV-2 infection. Seroprevalence studies can provide related data on HCWs who have a history of infections. According to numerous seroepidemiological reports of COVID-19 in different groups and the lack of seroepidemiological reports of COVID-19 in HCWs in Rafsanjan, the aim of this study was to determine the SARS-CoV-2 seroprevalenc...

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Journal: :Journal of virology 2007
Matthew Frieman Boyd Yount Mark Heise Sarah A Kopecky-Bromberg Peter Palese Ralph S Baric

The host innate immune response is an important deterrent of severe viral infection in humans and animals. Nuclear import factors function as key gatekeepers that regulate the transport of innate immune regulatory cargo to the nucleus of cells to activate the antiviral response. Using severe acute respiratory syndrome coronavirus (SARS-CoV) as a model, we demonstrate that SARS-COV ORF6 protein ...

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Journal: :Biochemical and biophysical research communications 2005
Jinzhu Duan Xiyun Yan Xueming Guo Wuchun Cao Wei Han Cai Qi Jing Feng Dongling Yang Guangxia Gao Gang Jin

An immune antibody phage-display library was constructed from B cells of SARS convalescent patients. More than 80 clones were selected from the library by using the whole inactivated SARS-CoV virions as target. One human scFv, B1, was characterized extensively. The B1 recognized SARS pseudovirus in vivo and competed with SARS sera for binding to SARS-CoV with high affinity (equilibrium dissocia...

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2003
Isao Arita Kazunobu Kojima Miyuki Nakane

(SARS-CoV) (1). The first case of SARS, diagnosed as communicable atypical pneumonia, occurred in Guangdong Province, China, in November 2002. Thousands of patients with SARS have been reported in over 30 countries and districts since February 2003. SARS is clinically characterized by fever, dry cough, myalgia, dyspnea, lymphopenia, and abnormal chest radiograph results (1–3). According to the ...

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Journal: :The Journal of infectious diseases 2005
Gabriella A Farcas Susan M Poutanen Tony Mazzulli Barbara M Willey Jagdish Butany Sylvia L Asa Peter Faure Poolak Akhavan Donald E Low Kevin C Kain

Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lun...

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Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005
Matthias Niedrig Katrin Leitmeyer Wilina Lim Malik Peiris John S Mackenzie Maria Zambon

To confirm an infection with the new coronavirus (SARS-CoV) causing the severe acute respiratory syndrome (SARS) diagnostic assays for detection of SARS-CoV specific antibody are necessary. To evaluate the diagnostic performance of laboratories an external quality assurance (EQA) study was performed in 2004. Participating laboratories (9/20) correctly detected anti-SARS antibodies in serum samp...

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