Protein structure classification hierarchically clusters domain structures based on structure and/or sequence similarities and plays important roles in the study of protein structure-function relationship and protein evolution. Among many classifications, SCOP and CATH are widely viewed as the gold standards. Fold classification is of special interest because this is the lowest level of classif...

SUPERFAMILY provides structural, functional and evolutionary information for proteins from all completely sequenced genomes, and large sequence collections such as UniProt. Protein domain assignments for over 900 genomes are included in the database, which can be accessed at http://supfam.org/. Hidden Markov models based on Structural Classification of Proteins (SCOP) domain definitions at the ...

The SUPERFAMILY resource provides protein domain assignments at the structural classification of protein (SCOP) superfamily level for over 1400 completely sequenced genomes, over 120 metagenomes and other gene collections such as UniProt. All models and assignments are available to browse and download at http://supfam.org. A new hidden Markov model library based on SCOP 1.75 has been created an...

MOTIVATION To investigate structure-function relationships, life sciences researchers usually retrieve and classify proteins with similar substructures into the same fold. A manually constructed database, SCOP, is believed to be highly accurate; however, it is labor intensive. Another known method, DALI, is also precise but computationally expensive. We have developed an efficient algorithm, na...

OBJECTIVES An important aspect of furthering our understanding of the central nervous system function after menopause is to examine the cerebral circuitry that appears to be influenced by cholinergic antagonist drugs in the presence and absence of estrogen. This pilot study investigated the effects of two anticholinergic drugs on brain activation and working memory performance in postmenopausal...

Rust fungi in the genus Phragmidium are frequent pathogens of both wild and cultivated roses. We investigated the occurrence and relationships of rusts on dog roses, Rosa sect. Caninae (Rosa canina, R. corymbifera and R. rubiginosa) in Germany. Two Phragmidium species, P. mucronatum and P. tuberculatum, were able to infect each of the three dog rose species examined. However, the overall infect...

REFERENCES Bull, D. R., and Burnet, F. M. (1943). Med. J. Aust., 1, 389. Burnet, F. M. (1942). Ibid., 1, 673. (1943). Ibid., 1, 385. Chalkina, 0. M. (1938). Arkh. biol. nauk., 52, 126. Isaacs, A., Negroni, G., and Tyrrell, D. A. J. (1957). Lancet, 2, 886. and Roden, A. T. (1956). Ibid., 2, 697. Mawson, J., and Swan, C. (1943). Med. J. Aust., 1, 394. Meiklejohn, G. (1960). J. Amer. med. Ass., 17...