New therapies are urgently needed against melanoma, one of the most aggressive tumors. Melanoma cells are resistant to the antifolate methotrexate (MTX), since MTX is taken up by the folate receptor-α (FRα), sequestered in melanosomes and exported out of the cell. The bisphosphonate zoledronic acid (ZOL) is active in several non-skeletal tumors; however, its antitumoral activity is hampered by ...

To study the effects of posture and meal structure on gastric emptying and satiety, nine women ingested tomato soup and then immediately or 20 min later an egg sandwich, when seated and when supine. The lag time was not different, but the half-emptying time of the sandwich was 32% longer (P < 0.01) and the emptying rate after the lag phase was 39% slower (P < 0.01) when the subjects were supine...

This paper deals with analysis of flexural stiffness, indentation and their energies in three point loading of sandwich beams with composite faces from Eglass/epoxy and cores from Polyurethane or PVC. Energy is consumed in three stages of indentation in laminated beam, indentation of sandwich beam and bending of sandwich beam. Theory of elasticity is chosen to present equations for indentation ...

BACKGROUND Small molecules classified as haptens are generally measured by competitive immunoassay, which is theoretically inferior to noncompetitive sandwich immunoassay in terms of sensitivity and specificity. We created a method for developing sandwich immunoassays to measure haptens on the basis of antimetatype antibodies. METHODS We generated antimetatype monoclonal antibodies against a ...

BACKGROUND Tropical fasciolosis caused by Fasciola gigantica infection is one of the major diseases infecting ruminants in the tropical regions of Africa and Asia including Thailand. Parasitological diagnosis of fasciolosis is often unreliable and possesses low sensitivity. Therefore, the detection of circulating parasite antigens is thought to be a better alternative for diagnosis of fasciolos...

Let d 2 D = {1, . . . , 9}, and let k be a positive integer with gcd(k, 10d) = 1. Define a sequence {sn(k, d)}n=1 by sn(k, d) := k dd . . . d | {z } n k. We say k is a d-composite sandwich number if sn(k, d) is composite for all n 1. For a d-composite sandwich number k, we say k is trivial if sn(k, d) is divisible by the same prime for all n 1, and nontrivial otherwise. In this paper, we develo...

in the current study, two line with short-term divergent selection for high weight (hw) and low weight (lw) at 4 wk of age after 7 generation were analyzed in coturnix japonica quail. hw line was significantly higher than lw line at 28d of age (p<0.01). 21 females, and 11 male from the hw, 18 females plus 10 male from the lw lines were mated as reciprocal cross and within lines to produce hh, l...

background patients with intellectual disabilities may be treated with antipsychotic medications for a variety of diagnoses. use of this category of medication can increase prolactin levels and place the patient at risk for sexual dysfunction and lower bone mineral density. the proposed mechanism of action is affinity for the dopamine receptor. use of bromocriptine, a dopamine receptor antagoni...