Bone morphogenetic protein (BMP-6, also known as vegetal-pale-gene-related and decaplentaplegic-vegetal-related) is a member of the transforming growth factor-beta superfamily of multifunctional signaling molecules. BMP-6 appears to play various biological roles in developing tissues, including regulation of epithelial differentiation. To study the possible involvement of BMP-6 in normal and ne...

The submandibular gland is involved in only 5% to 10% of the salivary gland tumors, and pleomorphic adenoma (PA) is the most common tumor affecting it. This study describes the clinicopathological features and immunohistochemical expression of Ki-67 and p53 in 60 cases of submandibular salivary gland PAs. Most of the patients were in the third and fifth decades of life and 37 (62%) of them were...

The objective of this study was to analyze the significance and potential value of heat shock proteins (HSPs) in salivary gland tumors. We found that expression of HSP60, HSP70, HSP86 and HSP84 were all upregulated in both salivary gland benign tumors and malignant tumors, and that the expression of HSP70, HSP86 and HSP84 was more greatly overexpressed in the malignant tumors (each P<0.01). For...

introduction: salivary gland tumors are relatively rare and constitute 3-4% of all head and neck neoplasms. the majority (70%) of salivary gland tumors arise in the parotid gland. recommended treatment for a parotid mass is surgical excision with a surrounding cuff of normal tissue to prevent recurrence. materials and methods: this is a retrospective study of 300 patients who were operated by a...

discussion benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity. although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasized to distinct sites. it remains to be determined whether this benign metastasizing pleomorphic adenoma is really low grade salivary malignancy. ...

Salivary gland diseases in children are rare, apart from viral-induced diseases. Nevertheless, it is essential for the otolaryngologist to recognize these uncommon findings in children and adolescents and to diagnose and initiate the proper treatment. The present work provides an overview of the entire spectrum of congenital and acquired diseases of the salivary glands in childhood and adolesce...

PURPOSE We investigated the methylation status and protein expression of four tumor suppressor genes to determine their role in salivary gland tumorigenesis. EXPERIMENTAL DESIGN We performed methylation-specific PCR and protein analyses of 29 normal salivary glands, 23 benign, and 79 malignant salivary gland neoplasms to determine the pattern and potential diagnostic and/or biological role of...

Adenoid cystic carcinoma (AdCC) is a malignant neoplasm, which accounts for 5-10% of all salivary gland tumors (1). About 50% of these tumors originate from intraoral minor salivary glands usually in the hard palate (1). Three clinically obvious characteristics of AdCC include slow growth rate, perineural invasion and high incidence of distant metastasis (1). The most commonly-affected sites of...

A 67-year-old male with three synchronous tumors in the unilateral parotid gland is reported. Postoperative histological examinations confirmed the presence of three synchronous primary tumors, specifically pleomorphic adenoma, Warthin's tumor and salivary duct carcinoma, in the right parotid gland. To our knowledge, this is the first case report describing three different histological types in...

Background: Salivary gland tumors are the most complex and diverse of any organ in body. Assessing pathological characteristics salivary tumor, contributing to early diagnosis effective treatment as well avoiding tumor-induced complications is focus study. Objective: To study clinical, paraclinical features evaluate results tumor surgery. Materials Methods: 41 patients with who were examined at...