Huge unrealized post-genome opportunities remain in the understanding of detailed molecular mechanisms for Alzheimer Disease (AD). In this work, we developed a computational method to rank-order AD-related proteins, based on an initial list of AD-related genes and public human protein interaction data. In this method, we first collected an initial seed list of 65 AD-related genes from the OMIM ...

Online Mendelian Inheritance in Man (OMIMTM) is a timely, authoritative compendium of bibliographic material and observations on inherited disorders and human genes. It is the continuously updated electronic version of Mendelian Inheritance in Man (MIM). MIM was last published in 1998 (1) and is authored and edited by Dr. Victor A. McKusick and a team of science writers, editors, scientists, an...

Databases such as MEDLINE, OMIM, RefSeq and LocusLink serve as important information sources for biomedical studies. A search of several databases can yield vast quantities of information, so much in fact that the searcher may struggle to pinpoint the important information. This has highlighted the desirability of a specific tool to facilitate efficient database searching and extraction of info...

McKusick's Online Mendelian Inheritance in Man (OMIM; http://www.ncbi.nlm.nih.gov/omim), a knowledgebase of human genes and phenotypes, was originally published as a book, Mendelian Inheritance in Man, in 1966. The content of OMIM is derived exclusively from the published biomedical literature and is updated daily. It currently contains 18,961 full-text entries describing phenotypes and genes. ...

Manual annotation of biological data cannot keep up with data production. Open annotation models using wikis have been proposed to address this problem. In this empirical study we analyse 36 years of knowledge collection by 738 authors in two Molecular Biology wikis (EcoliWiki and WikiPathways) and two knowledge bases (OMIM and Reactome). We rst investigate authorship metrics (authors per entry...

Researchers in the biomedical and molecular biology fields are faced with a wide variety of information sources. These are presented in the form of images, free text, and structured data files that include medical records, gene and protein sequence data, and whole genome microarray data, all gathered from a variety of experimental organisms and clinical subjects. The need to organize and relate...

Ziel dieser Bachelorarbeit ist die Erstellung und Visualisierung einer Krankheitsontologie basierend auf Daten der “Disease Ontology“ [1] und die Abbildung von KrankheitsMutations-Relationen aus den Datenbanken OMIM [2], COSMIC [3],GAD [4] und GeneView [5] auf diese Ontologie. Anschließend soll eine Netzwerkanalyse auf Krankheits-Gen Ebene durchgeführt und mit Daten anderer Paper [6] [7] [8] ve...

489 0001-8244/01/1100-0489$19.50/0 © 2001 Plenum Publishing Corporation If there is any truth in the allegation that behavior geneticists like behaviors best when they show high heritability, then surely filling out an IQ test is the human behavior that makes us most happy. Extensive research based on twin, family, and adoption data has documented that more than half of the striking individual ...

Random walk on heterogeneous networks is a recently emerging approach to effective disease gene prioritization. Laplacian normalization is a technique capable of normalizing the weight of edges in a network. We use this technique to normalize the gene matrix and the phenotype matrix before the construction of the heterogeneous network, and also use this idea to define the transition matrices of...

Butyrylcholinesterase (BChE; EC 3.1.1.8; Online Mendelian Inheritance in Man (OMIM) number 177400) is an enzyme found in many human tissues and encoded by the BCHE gene, of which 65 variants have been identified. In a recent study we found that the -116A variant of exon 1 of the BCHE gene was associated with lower mean BChE activity. The present study analyzed the -116 single nucleotide polymor...