Mouse embryos homozygous for the T-mutation show abnormalities, severer at the posterior embryonic regions, by day 9 of gestation and die before day 11 in utero. To analyse development potentially of the T/T embryos fragments of their anterior and posterior portions were grafted into the testes of adult T/+ mice, and examined histologically for the tissues formed after 1 month. The grafted tiss...

Embryonic stem (ES) cells are promising for cardiac repair, but directing their differentiation toward cardiomyocytes remains challenging. We investigated whether the heart guides ES cells toward cardiomyocytes in vivo and whether allogeneic ES cells were immunologically tolerated. Undifferentiated mouse ES cells consistently formed cardiac teratomas in nude or immunocompetent syngeneic mice. C...

BACKGROUND In unaided caudal epidural block (CEB), incorrect needle insertion has been reported to occur in 15% to 38% of attempts. OBJECTIVE To statistically analyze the anatomical variables affecting difficult CEB using ultrasonographic measurement. METHODS Preprocedural ultrasonography was performed and the following measurements were obtained in 146 patients: the distance from the skin ...

Teratomas are rarely seen in adults, and presacral region is an area where they rarely settle in. Similarly, only about 1% of teratomas show malignant transformation. Malignant transformation is often associated with the area where teratoma settles in. Malignant transformation of mediastinal teratomas is more frequent than the ones located in retroperitoneal area and gonad. They most commonly s...

Transport if loaded uclear transporters can be viewed as taxis that move cargo across the nuclear envelope. On page 649, Plafker et al. report that importin-11, a nuclear transport receptor , may be an especially selective cabbie. Importin-11 transports UbcM2, a ubiquitin (Ub)-conjugating enzyme, but it does so only when the enzyme is charged with a Ub at its active site. UbcM2 is an E2 enzyme,...

Teratomas of the stomach are extremely rare, comprising only about 1% of all teratomas in the pediatric population [1,2]. The majority of cases are mature teratomas with less than two dozen reported cases of immature gastric teratoma [2-4]. Most reported gastric teratomas occur in the pediatric population and less commonly in adults. The most common location is the posterior wall or greater cur...

Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathways and thereby affect fundamental cellular processes, including proliferation, apoptosis, and differentiation. K-ras activating mutations play a key role in neoplastic progression and are particularly prevalent in colorectal, pancreatic, and lung cancers. The present study addressed whether the K...

Primary malignant neoplasms of the pericardium are rare and are predominantly mesotheliomas, followed by benign localized fibrous mesothelioma, malignant fibrosarcoma, angiosarcoma and benign and malignant teratomas. 1 This article concerns an atypical presentation of this malignant tumor with symptoms and signs of pericardial effusion. This unusual feature was complete encasement of the h...

Primary intradural teratomas are very rare tumors, only 20 cases have been reported [1-16]. Intraspinal teratomas are most often located in the dorsal aspect of the cervical or lower thoracic-upper lumbar regions. We report a case of an upper thoracic, ventrally located intraspinal teratoma associated with multiple spinal anomalies. The patient was evaluated by conventional myelography, CT metr...

Retroperitoneal teratomas are usually asymptomatic, though there have been isolated reports of retroperitoneal teratomas presenting as intra-abdominal abscesses and peritonitis in adults. A 7-year-old girl who had presented with acute abdomen due to ruptured retroperitoneal teratoma is reported.