Tay-Sachs disease (GM2 gangliosidosis, type 1; TSD) is an autosomal recessive GM2 gangliosidosis resulting from the deficient activity of the lysosomal hydrolase beta-hexosaminidase A (Hex A). With a carrier frequency estimated at 1 in 25, it is a common lysosomal disorder in the Ashkenazi Jewish population. Tay-Sachs disease has provided the prototype for the prevention of severe recessive gen...

BACKGROUND By late 1993, the genes for cystic fibrosis and Gaucher disease and the mutations common among Ashkenazi Jews had been identified. In response to these advances, heterozygote screening for cystic fibrosis and Gaucher disease was added to the more than 20-year-old Tay-Sachs disease screening program at New York University Medical Center, New York, NY. OBJECTIVE To review the outcome...

Jeffrey D Sachs tells Fiona Fleck why investing in renewable energy is good for our health, but why poor countries need more time to make the switch.

convexity theory and duality theory are important issues in math- ematical programming. within the framework of credibility theory, this paper rst introduces the concept of convex fuzzy variables and some basic criteria. furthermore, a convexity theorem for fuzzy chance constrained programming is proved by adding some convexity conditions on the objective and constraint functions. finally,...

in this paper the bagley-torvik equation as a prototype fractional differential equation with two derivatives is investigated by means of homotopy perturbation method. the results reveal that the present method is very effective and accurate.

A sociedade civil demanda cada vez mais a responsabilidade socioambiental dos entes públicos. Neste contexto, este artigo apresenta um estudo de caso realizado no município Maricá-RJ ao qual aborda social na gestão pública. pesquisa teve como objetivo analisar as ações do poder público cidade Maricá e discutir elas estão correlacionadas com cinco dimensões ecodesenvolvimento propostas por Sachs...