Dorsal Hippocampal neurons provide an allocentric map of space, characterized by three key properties. First, their firing is spatially selective, termed a rate code. Second, as animals traverse through place fields, neurons sustain elevated firing rates for long periods, however this has received little attention. Third the theta-phase of spikes within this sustained activity varies with anima...

Behavioral and physiological circadian rhythms are controlled by endogenous oscillators in animals. Voluntary wheel-running in rodents is thought to be an appropriate model of aerobic exercise in humans. We evaluated the effects of chronic voluntary exercise on the circadian system by analyzing temporal profiles of feeding, core body temperature, plasma hormone concentrations and peripheral exp...

BACKGROUND We aimed to identify factors associated with recurrent wheezing (RW) in infants in the first year of life living in the Southern region of São Paulo city and participating in the "Estudio Internacional de Sibilancias en Lactantes (EISL)" - phase 3 (P3). METHODS 1335 parents of infants who were attended in primary care health units in the Southern region of São Paulo city from 2009 ...

We combine concepts from random matrix theory and free probability together with ideas from the theory of commutator length in groups and maps from surfaces, and establish new connections between the two. More particularly, we study measures induced by free words on the unitary groups U (n). Every word w in the free group Fr on r generators determines a word map from U (n) to U (n), defined by ...

UNLABELLED All the opinions in this article are those of the authors and should not be construed to reflect, in any way, those of the Department of Veterans Affairs. BACKGROUND Our study purpose was to assess the predictive validity of reviewer quality ratings and editorial decisions in a general medicine journal. METHODS Submissions to the Journal of General Internal Medicine (JGIM) betwee...

PURPOSE To describe dose-volume values with the use of water alone vs. a rectal balloon (RB) for the treatment of prostate cancer with proton therapy. MATERIALS AND METHODS We analyzed 30 proton plans for 15 patients who underwent CT and MRI scans with an RB or water alone. Simulation was performed with a modified MRI endorectal coil and an RB with 100 mL of water or water alone. Doses of 78-...

BACKGROUND Frequent chronic obstructive pulmonary disease (COPD) exacerbation is a major cause of hospital admission and mortality. It has been reported that Traditional Chinese Medicine (TCM) may relieve COPD symptoms and reduce the incidence of COPD exacerbations, thus improving life quality of COPD patients. The acute exacerbation of COPD risk-window (AECOPD-RW) is the period after an exacer...

The hippocampal cognitive map is thought to be driven by distal visual cues and self-motion cues. However, other sensory cues also influence place cells. Hence, we measured rat hippocampal activity in virtual reality (VR), where only distal visual and nonvestibular self-motion cues provided spatial information, and in the real world (RW). In VR, place cells showed robust spatial selectivity; ho...

Random walk (RW) method has been widely used to segment the organ in the volumetric medical image. However, it leads to a very large-scale graph due to a number of nodes equal to a voxel number and inaccurate segmentation because of the unavailability of appropriate initial seed point setting. In addition, the classical RW algorithm was designed for a user to mark a few pixels with an arbitrary...