In this paper we discuss the design and use of a fault tolerant MPI (FT-MPI) that handles process failures in a way beyond that of the original MPI static process model. FT-MPI allows the semantics and associated modes of failures to be explicitly controlled by an application via a modified functionality within the standard MPI 1.2 API. Given is an overview of the FT-MPI semantics, architecture...

Future high-performance computing systems may face frequent failures with their rapid increase in scale and complexity. Resilience to faults has become a major challenge for large-scale applications running on supercomputers, which demands fault tolerance support for prevalent MPI applications. Among failure scenarios, process failures are one of the most severe issues as they usually lead to t...

MPI is routinely used for writing parallel applications, but it is not commonly used for writing long-running parallel services, such as parallel file systems or job schedulers. Nonetheless, MPI does have many features that are potentially useful for writing such software. Using the PVFS2 parallel file system as a motivating example, we studied the needs of software that provide persistent para...

Presently, di erent vendors' MPI implementations cannot interoperate directly with each other. As a result, performance of distributed computing across di erent vendors' machines requires use of a single MPI implementation, such as MPICH. This solution may be sub-optimal since it cannot utilize the vendors' own optimized MPI implementations. PVMPI, a software package currently under development...

Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial obstruction increases pulmonary vascular resistance (PVR) leading to right ventricle (RV) failure. Progression and survival of patients with PAH are related to the ability of the RV to adapt to the chronically elevated pulmonary artery pressure (PAP), 1) hence, RV function is an important determinant of prognosis in...

Since systemic sclerosis (SSc) also involves the heart, the aim of the present study was to evaluate possible differences in right ventricular (RV) pump function between SSc-associated pulmonary arterial hypertension (PAH; SScPAH) and idiopathic PAH (IPAH). In 13 limited cutaneous SScPAH and 17 IPAH patients, RV pump function was described using the pump function graph, which relates mean RV pr...

To produce fish of a high quality that are rich in omega-3 fatty acids (n-3 FA) and simultaneously generate more sustainable aquaculture, the combined use of phytochemicals and vegetable oils in fish feed seems to be a promising approach. Resveratrol (RV) potentially induces endogenous fatty acid synthesis, resulting in elevated n-3 FA levels in fish. RV putatively influences ∆6-desaturase, the...

BACKGROUND Although proximal right coronary artery (RCA) occlusion is the culprit commonly responsible for acute right ventricular (RV) infarction (RVI), the severity of RV dysfunction ranges broadly. This study was designed to delineate the patterns of coronary compromise that determine the magnitude of RV ischemic dysfunction. METHODS AND RESULTS In 125 patients with acute inferior myocardi...

BACKGROUND Pulmonary hypertension (PH) causes elevated right ventricular (RV) systolic pressure, RV remodeling and finally RV failure to death. However, the mechanisms of RV remodeling in PH remain to be fully elucidated. METHODS AND RESULTS RV autopsy samples from 6 PH patients with RV failure against 3 age- and sex-matched controls were first examined. Next, RV remodeling in 2 mouse models ...

Rhinovirus-(RV-) induced asthma exacerbations account for high asthma-related health costs and morbidity in Australia. The cellular mechanism underlying this pathology is likely the result of RV-induced nuclear-factor-kappa-B-(NF-κB-) dependent inflammation. NF-κB may also be important in RV replication as inhibition of NF-κB inhibits replication of other viruses such as human immunodeficiency ...