Multinuclear platinum anticancer complexes are a proven option to overcome resistance of established anticancer compounds. Transferring this concept to ruthenium complexes led to the synthesis of dinuclear Ru(II)-arene compounds containing a bis(pyridinone)alkane ligand linker. A pronounced influence of the spacer length on the in vitro anticancer activity was found, which is correlated to the ...

In the title compound, [Ru(C10H14)(C12H9N3)(CH3CN)][SbF6]2, the ruthenium(II) cation is η (6)-coordinated by the para-cymene ligand with a Ru-centroid(η (6)-benzene) distance of 1.746 (2) Å. Furthermore, ruthenium coordinations to the C and N atoms of the pyrimidyl indole ligand are found to be 1.986 (4) and 2.082 (3) Å, respectively. The typical piano-stool coordination environment is saturate...

There is considerable interest in the interactions of ruthenium (Ru)(II) complexes with DNA as well as the biological impact of the interactions. Here, by using isothermal titration calorimetry, viscosity measurement, and circular dichroism, we investigated the interactions of a new Ru(II) complex, [Ru(dmp)(2)PMIP](2+){dmp = 2,9-dimethyl-1,10-phenanthroline, PMIP = 2-(4-methylphenyl)imidazo[4,5...

Photoelectroanalytical chemistry, the application of photoelectrochemistry to analysis, as reported here, is based on the amperometric detection of tris(2,2'-bipyridine)ruthenium(III) after its production from the corresponding Ru(II) complex in an excited state and quenching by electron transfer. The Ru(II) complex is detectable in concentrations less than 10(-10) mol/L injected into a flow st...

The synthesis and characterization of new bis(bipyridine)ruthenium(II) ferrocenyl ?-diketonate complexes, [(bpy)2Ru(Fc-acac)][PF6] (bpy=2,2?-bipyridine; Fc-acac=functionalized ligand) are reported. Alongside clinical platinum drugs, these bimetallic ruthenium-iron complexes have been screened for their cytotoxicity against MIA PaCa-2 (human pancreatic carcinoma), HCT116 p53+/+ colon carcinoma, ...