Orphan nuclear receptor fetoprotein transcription factor (FTF) was previously identified as a specific regulator of the alpha(1)-fetoprotein gene during early liver development and in response to hormonal signals (L. Galarneau, J.-F. Paré, D. Allard, D. Hamel, L. Lévesque, J. D. Tugwood, S. Green, and L. Bélanger, Mol. Cell. Biol. 16:3853-3865, 1996). Here we report a functional analysis of FTF...

Problem statement: In this study, we proposed a new algorithm M-SMFTF for adaptive filtering with fast convergence and low complexity. Approach: It was the result of a simplified FTF type algorithm, where the adaptation gain was obtained only from the forward prediction variables and using a new recursive method to compute the likelihood variable. Results: The computational complexity was reduc...

Understanding the molecular mechanisms of the specific interaction between transcription factor proteins and DNA is key to comprehend the regulation of gene expression and to develop technologies to engineer transcription factors. Thus far, although there have been several attempts to elucidate protein-DNA interaction through amino acid-base recognition codes, sequence based profiles, or physic...

BACKGROUND Internet based cognitive behavioural therapy (iCBT) has been demonstrated to be cost- and clinically effective. There is a need, however, for increased therapist contact for some patient groups. Combining iCBT with traditional face-to-face (ftf) consultations in a blended format (B-CBT) may produce a new treatment format with multiple benefits from both traditional CBT and iCBT such ...

4 Objective 5 To investigated the validity over time of Fingertip-to-floor test (FTF) and Straight leg raising 6 test (SLR) using Roland Morris disability Questionnaire (RMDQ) and correlation coefficient 7 (r) and to assess the predictive value of factors related to the change in RMDQ over 12 8 months using multivariate regression analysis. 9

A four lesson diabetes curriculum and two discussion sessions, focusing on diabetes self-management (diet, medication, physical activity) were delivered via two educational modalities: 1) Traditional Face-to-Face (FTF) Classes and 2) Virtual Diabetes Education (VDE) Classes administered in the Second Life® virtual world. The purpose of the study was to 1) describe the psychosocial outcomes in y...

A non-nucleosidic compound, Helioxanthin (HE-145), was found to suppress HBV gene expression and replication in HCC cells. To understand the molecular mode of action of HE-145 on HBV gene expression, the effects of HE-145 on four viral promoter activities using luciferase as a reporter were examined. It was found that HE-145 selectively suppresses surface antigen promoter II (SPII) and core pro...

Liver receptor homolog 1 (Lrh1, also known as Nr5a2) belongs to the orphan nuclear receptor superfamily and has diverse functions in development, metabolism, and cell differentiation and death. Lrh1 regulates the expression of Oct4, which is a key factor of early embryonic differentiation. However, the role of Lrh1 in early development of mammalian embryo is unknown. In the present study, the l...

BACKGROUND Melanoma cases may exist in pancreatic cancer kindreds, whereas there is increased risk of pancreatic cancer in familial melanoma. The two cancers may share genetic susceptibility variants in common. METHODS Three dbGaP (datasets in Genotypes and Phenotypes)-deposited GWAS (genome-wide association study) datasets (MD Anderson melanoma, PanScan 1, and PanScan 2 for pancreatic cancer...

Among species of the heterobasidiomycetous yeasts, Filobasidiella neoformans is the only serious pathogen that causes fatal infections in both immunocompromised as well as immunocompetent patients. Three phenotypic characteristics, including growth at 37 degrees C, extracellular polysaccharide capsule and laccase activity, of F. neoformans are known to play major roles in the pathogenicity of t...