The excess pore water pressure generated under the combined vertical and horizontal earthquake excitations is generally greater than that unidirectional excitation, which may further affect dynamic response of soil-pile-superstructure-quay wall (SPSQ) system. This study conducted a coupled effective-stress analysis for SPSQ system to liquefaction-induced lateral displacement excitations. To acc...

The diagnostic work-up of acute promyelocytic leukemia (APL) includes the cytogenetic demonstration of the t(15;17) translocation and/or the PML-RARA chimeric transcript by RQ-PCR or RT-PCR. This latter assays provide suitable results in 3-6 hours. We describe here two new, rapid and specific assays that detect PML-RARA transcripts, based on the RT-QLAMP (Reverse Transcription-Quenching Loop-me...

BACKGROUND Acute inhalation of clinical doses of salbutamol in normal volunteers increases resting metabolic rate by up to 20% above control values. This study was designed to see if chronic treatment with salbutamol causes a sustained increase in metabolic rate and whether it modifies the acute thermogenic response to the drug. METHODS The effects of chronic inhaled salbutamol on resting oxy...

INTRODUCTION The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro. METHODS Human breast tissue specimens (malignant n = 75, normal n = 15, fibroadenoma n = 10)...

The purpose of this study was to screen cancer-related genes and to identify histopathological gene expression patterns as potential biomarkers in human epithelial ovarian cancer (EOC). Fifty genes were screened by reverse-transcription polymerase chain reaction assay with cDNA from 83 EOC tissues and 48 normal ovarian specimens of ovarian cancer patients and evaluated by gel electrophoresis an...

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An ecological risk assessment (ERA) was conducted for Shadegan Wetland in Iran. The objective of this study was to assess the risk to phytoplankton, zooplankton, invertebrate, insect larvae, and fish affected by pesticide in Shadegan Wetland. Five pesticides (DDT, Aldrine, Dieldrin, Ametryn and Lindane) were assessed to evaluate the impact to aquatic community in the Shadegan Wetland. The risk ...

In this paper we present a way to use precision and recall measures in total absence of ground truth. 1 Precision and Recall 1.1 General Definitions and Notation Precision Pr and Recall Rc (and often associated F-measure or ROC curves) are standard metrics expressing the quality of Information Retrieval methods [8]. They are usually expressed with respect to a query q (or averaged over a series...

BACKGROUND Peptidyl-prolyl cis/trans isomerase (Pin1), encoded by PIN1 gene with locus in chromosome 19p13, is an enzyme that catalytically induces conformational changes in proteins after phosphorylation on serine or threonine residues preceding proline (pSer/Thr-Pro motifs); in this way, it has an influence on protein interactions and intracellular localizations of proteins. The aim of the st...

BACKGROUND Circadian rhythm has been shown to be related to glucose metabolism and risk of diabetes, probably through effects on energy balance. Recent genome-wide association studies identified variants in circadian rhythm-related genes (CRY2 and MTNR1B) associated with glucose homeostasis. OBJECTIVE We tested whether CRY2 and MTNR1B genotypes affected changes in measures of energy expenditu...