Stroke survivors often recover from motor deficits, either spontaneously or with the support of rehabilitative training. Since tonic GABAergic inhibition controls network excitability, it may be involved in recovery. Middle cerebral artery occlusion in rodents reduces tonic GABAergic inhibition in the structurally intact motor cortex (M1). Transcript and protein abundance of the extrasynaptic G...

Effects of multiple-dose regimens (oral, daily, once a day for 15 days) cyclooxygenase (COX) inhibitors etoricoxib (1 and 10 mg/kg), diclofenac sodium 5 mg/kg) their combinations with 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol 25 on rat behavior were studied in the open field test, rotarod test elevated plus maze test. Exploratory (in test) locomotor rats was significantly weakened o...

PURPOSE Long term L-DOPA therapy in Parkinson's disease is associated with troublesome motor fluctuations such as L -DOPA Induced dyskinesia and wearing off effect. Our recent study showed that activation of 5-HT1A receptors could improve the anti-cataleptic effect of L-DOPA in parkinsonian rats. In this study we investigated the effect of fluoxetine on anti-parkinsonian effect of L-DOPA in 6-h...

OBJECTIVE To evaluate the effect of K+ channels inhibitors in treatment of parkinson`s disease (PD). METHODS This prospective comparative study was conducted in the Qazvin University of Medical Sciences, Iran, from April 2015 to January 2016. Male rats (n=37) received intraperitoneal doses of TEA (2 and 5 mg/kg) or 4-AP (0.5 and 1 mg/kg) twice-daily, before a stereotactic injection of 6-hydro...

background and objective: parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. in recent years, there have been interests in the role of the free radical damage in pd. cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. this research focused on the effects of cinnamon extract and cinn...

Motor and behavioral abnormalities are common presentations among individuals with HIV-1 associated neurocognitive disorders (HAND). We investigated whether longitudinal motor and behavioral performance in the HIV-1 transgenic rat (Tg), a commonly used neuro-HIV model, corresponded to in vivo neuronal death/dysfunction, by using rotarod and open field testing in parallel to [18F] 2-fluoro-2-deo...

introduction: motor behavior and coordination impairment are known side effects of opioid treatment, yet very few studies have investigated the effects of tramadol on motor behavior, or compared its effect with the effect of an opioid. this study investigates the effects of chronic injection of morphine and tramadol on rat motor function during infancy. methods: neonate rats (n=56) were randoml...

Exercise has been recommended to improve motor function in Parkinson patients, but its value in altering progression of disease is unknown. In this study, we examined the neuroprotective effects of running wheel exercise in mice. In adult wild-type mice, one week of running wheel activity led to significantly increased DJ-1 protein concentrations in muscle and plasma. In DJ-1 knockout mice, run...