PURPOSE The purpose of this study was to analyze the antimicrobial, antioxidant activity and cytotoxicity of Dendropanax morbifera Léveille extract for assessing whether Dendropanax morbifera Léveille can be used for the development of natural mouthwash and denture cleaning solution. MATERIALS AND METHODS The extract was obtained from branches of Dendropanax morbifera Léveille. The solvent fr...

The pharmacokinetics of apalcillin and piperacillin, each administered intravenously as a single 2-g dose, were compared in 10 volunteers in a randomized study of crossover design using bioassay and high-pressure liquid chromatographic procedures. The concentrations of both penicillins in serum were determined over a period of 12 h and in urine over 24 h. Concentrations of apalcillin and pipera...

Among gram-negative bacilli isolated from burn wound cultures, some strains of Enterobacteriaceae were resistant to tobramycin (minimal inhibitory concentration [MIC ]> 20 ,g/ml) but susceptible to gentamicin (MIC < 5 ,gg/ml). One Klebsiella pneumoniae and two Enterobacter cloacae strains were selected for studies on their mechanisms of resistance to aminoglycoside antibiotics. Resistance to hi...

The relative ability of 44 erythromycin analogues to bind to ribosomes was determined by their effect on ['4C]erythromycin binding to Escherichia coli ribosomes. The association and dissociation constants of each of these erythromycin derivatives were determined as well as their interaction coefficient for their binding to ribosomes. Substitutions were made on various portions of the erythromyc...

Micro-Media Systems (MMS) has developed a procedure by which microdilution trays can be filled with dilutions of antimicrobial agents, frozen, and distributed to clinical laboratories. The trays are prepared in various distribution centers throughout the United States to supply clinical laboratories in the vicinity of each center. For use, trays are removed from the freezer, allowed to thaw, an...

BACKGROUND In this study, Salvia verbenaca L. aerial part extracts (SVEs): were screened for their antihemolytic, xanthine oxidase (XO) inhibition, antioxidant and antimicrobial activities. MATERIAL AND METHODS To investigate SVEs antihemolytic activity, the 2,2,-azobis (2-amidinopropane) dihydrochloride (AAPH) was used to induce erythrocyte oxidative hemolysis. In XO inhibition test, xanthin...

The Isatis species has antibacterial, anticancer and antiviral properties and these important endemic plants grow widely in various parts of Anatolian-Turkey. In the present study, the antioxidant activities of Isatis floribunda Boiss. ex Bornm. flower and root extracts were determined with total antioxidant activity, free radical scavenging activity, ferric ion reducing power, and cupric ion r...

Gentamicin Clb is 6'-N-methylgentamicin Cia. This antibiotic is coproduced, as one of minor components, in the standard gentamicin fermentation. Kershner (Ph.D. thesis, Rutgers University, New Brunswick, N.J., 1971) first described its presence in trace amounts in gentamicin preparations. Daniels and co-workers (2) reported its isolation, purification, and characterization from fermentation bot...

Use of Nonlinear Mixed-Effects Analysis for Improved Precision of Early Pharmacodynamic Measures in Tuberculosis Treatment Geraint R. Davies,* Richard Brindle, Saye H. Khoo, and Leon J. Aarons Wellcome Trust Centre for Clinical Tropical Medicine, University of Liverpool, Liverpool, United Kingdom; Department of Clinical Microbiology, Portsmouth Hospitals, Portsmouth, United Kingdom; Department ...

Hyperacute infections, i.e., infections which are often fatal within 24 hours from the onset of symptoms, and resistant strains of organisms, account for the vast majority of failures in the use of antibiotics. A few cases cannot be classified into either category and remain as unexplained failures. The magnitude of the problem of hypenacute infections can be judged by the fact that in a contag...