To the Editor: Alternative strategies to reduce the onset time of nondepolarizing muscle relaxants, such as priming,1 administering large doses2 and using the timing principle3,4 have not been completely succesful. We have used a propofolrocuronium mixture for the rapid induction of anesthesia. First however, we tested whether a propofol-rocuronium mixture is stable. UV spectra were obtained on...

Introduction: Suxamethonium chloride was a time-tested depolarizing muscle relaxant with quick onset of action and produced excellent intubating conditions but it is contraindicated and hazardous in certain situations. Rocuronium bromide had the most rapid onset, intermediate duration of action, minimal cardiovascular side effects, and no histamine release emerged as a good alternative. Purpose...

BACKGROUND Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated in Caucasian patients, providing rapid reversal of moderate (reappearance of T2) rocuronium-induced NMB. We investigated the efficacy and safety of sugammadex versus neostigmine in Korean patients. METHODS ...

BACKGROUND Sugammadex reverses neuromuscular block (NMB) through binding aminosteroid neuromuscular blocking agents. Although sugammadex appears to be highly selective, it can interact with other drugs, like corticosteroids. A prospective single-blinded randomized clinical trial was designed to explore the significance of interactions between dexamethasone and sugammadex. METHODS Sixty-five p...

BACKGROUND The aims of this study were to compare the efficacy of sevoflurane inhalation alone, intravenous remifentanil alone, and the combination of sevoflurane inhalation and remifentanil as pretreatment for the prevention of rocuronium-induced withdrawal movement in pediatric patients. METHODS In this prospective, randomized study, 90 American Society of Anesthesiologists physical status ...

BACKGROUND Withdrawal movement during rocuronium injection is a common, unresolved adverse effect. We aimed to investigate the effect of IV acetaminophen pretreatment on withdrawal movement during rocuronium injection. METHODS This study enrolled 120 American Society of Anesthesiologists (ASA) I-II patients undergoing general anesthesia. They were randomly assigned to three treatment groups. ...

Background: Succinylcholine remain unsurpassed in providing ideal intubating conditions in the shortest time among all available neuromuscular blocking agents hence is advocated as the drug of choice for rapid sequence endotracheal intubation. Aim: Study compared the effects of succinylcholine and rocuronium bromide on intraocular pressure. Materials and methods: Study was done in 30 samples of...

Sugammadex is the first clinical representative of a new class of drugs called selective relaxant binding agents. It has revolutionized the way anesthesiologists think about drug reversal. Sugammadex selectively binds rocuronium or vecuronium, thereby reversing their neuromuscular blocking action. Due to its 1:1 binding of rocuronium or vecuronium, it is able to reverse any depth of neuromuscul...

BACKGROUND AND OBJECTIVES Rocuronium is an intermediate nondepolarizing neuromuscular blocker (NMB) with faster onset and indicated in situations requiring rapid tracheal intubation. Intravenous lidocaine is often used to decrease hemodynamic responses to tracheal intubation. The association of NMB to local anesthetics results in potentiation of NMB effects. The purpose of this study was to eva...

BACKGROUND Rapid tracheal intubation with rocuronium has not been studied using a probability-based approach. The authors aimed to predict doses of rocuronium giving 90% and 95% probability of in intubation within 60 s and to estimate their durations of action. METHODS After premedication with midazolam, 2 mg, anesthesia was induced in 80 subjects with fentanyl, 2 microg/kg, followed 3 min la...