This study investigated the effect of the Rho kinase inhibitor Y-27632 and fasudil on the development of human mesangial cell (HMC) inflammation and fibrosis induced by high glucose and to clarify the contribution of the Rho/ROCK signaling pathway in the pathogenesis of diabetic kidney disease (DKD). High glucose (30 mmol/l) induced the Rho/ROCK signaling pathway. Western blotting was used to d...

social rights is set of rights and supports that through which the welfare, prosperity and welfare to peak and lack of well-being reaches a minimum.. whereas in western systems, pro-government social rights new born and emerged dice the model socialist state& with the aim of deter the masses from resorting to socialist revolution, islam from the very early formation of their, been noted importa...

Introduction. Currently, Russia has adopted a course towards the creation of intelligent machines and equipment. The same holds for mobile technological road construction public utilities. Therefore, design this type actuators with self-adaptation function is critical task. Materials Methods. A device equipped hydraulic drive to load coordination kinematic power parameters principal motion feed...

The article discusses modern methods of strengthening foundations on artificial bases that have received excessive precipitation and rolls. In the course studies, it was found use bored piles allows transferring load to underlying reliable foundation at any depth, cementing soil contributes improving physical mechanical characteristics backfill soil.

Original scientific paper Aiming at answering the questions of wear and failure of hob in the rock breaking process, the rock breaking process was simulated in different broken rock conditions by using finite element method. The relationship between normal force, lateral force, rolling force and time was obtained by rock breaking simulation analysis on the single edge disc cutter. The rock stre...

We describe the design of an acoustic emission (AE) measurement assembly for reliable acquisition of a multi-year timeseries in steep alpine rock-walls. The motivation for collection of these data is to enhance understanding of freezinginduced rock damage. Because measurements in natural rock slopes are challenging, this study investigates technical options suitable to capture AE signals from d...

Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Introduction: We present preliminary work to characterize surface rock abundance at ExoMars Rover landing site candidates. A challenge in quantifying the a...

We have performed preliminary mapping of the manganese and iron present in a cross-section of a rock varnish from the Cima volcanic flows in the Mojave Desert, California. Rock varnish is a nanostratigraphic deposit found on typically fine-grained rocks in hyper-arid to semi-arid deserts (Figure 1a) [1]. Rock varnish is defined as consisting of about 70% clay particles held together by about 30...

1 Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 2 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 3 Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA 4 Division of Hematology and...