Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Whereas the molecular and cellular mechanisms governing astrocytoma invasion remain poorly understood, evidence in other cell systems has implicated a role for the Rho-GTPases in cell motility and invasion. Here, we examine how the inhibition or activation of Rho-kinase (ROCK) affects astro...

Chronic pulmonary hypertension in infancy and childhood is characterized by a fixed and progressive increase in pulmonary arterial pressure and resistance, pulmonary arterial remodeling, and right ventricular hypertrophy and systolic dysfunction. These abnormalities are replicated in neonatal rats chronically exposed to hypoxia from birth in which increased activity of Rho-kinase (ROCK) is crit...

The rho-associated kinase (ROCK) signaling pathway is activated via secreted bioactive molecules or via integrin activation after extracellular matrix binding. These lead to polymerization of actin stress fibers and formation of focal adhesions. Accumulating evidence suggests that actin cytoskeleton-modulating signals are involved in aqueous outflow regulation. Aqueous humor contains various bi...

The bacterial endotoxin or lipopolysaccharide (LPS) leads to the extensive vascular endothelial cells (EC) injury under septic conditions. Guanine nucleotide exchange factor-H1 (GEF-H1)/ROCK signaling not only involved in LPS-induced overexpression of pro-inflammatory mediator in ECs but also implicated in LPS-induced endothelial hyper-permeability. However, the mechanisms behind LPS-induced GE...

Morokweng is a large, 145 Ma impact structure in the Northwest Province of South Africa. The impact origin of this structure and its melt rock has been confirmed by ample evidence of shock metamorphism in clasts within the melt rock and samples from granitoid basement below the melt body. The age of this structure is indistinguishable from the biostratigraphic age of the Jurassic-Cretaceous (J-...

In this paper, a Bayesian framework is used to infer HiRISE-equivalent rock density from CTX image features without needing to explicitly identify rocks. The statistical relationship between HiRISE rock density and CTX image features is modeled using Bayesian Networks. The model is enriched by including geological features—specifically, geomorphic units. The geomorphic units are identified by g...

Neutrophil-induced coronary microvascular barrier dysfunction is an important pathophysiological event in heart disease. Currently, the precise cellular and molecular mechanisms of neutrophil-induced microvascular leakage are not clear. The aim of this study was to test the hypothesis that rho kinase (ROCK) increases coronary venular permeability in association with elevated endothelial tension...

ub lis he d by M an ey P ub lis hi ng ( c) IO M C om m un ic at io ns L td A methodology developed to estimate with accuracy the instantaneous specific rock energy using corrected downthe-hole (DTH) drill monitoring data is presented. A specific rock energy profile can be generated for every hole, and thus a drilling site can be mapped for this index. A special data acquisition system was devel...