BACKGROUND Cyperus rotundus L. was used in traditional Iranian medicine to treat memory and cognition disorders. The present study was aimed at investigating the effect of the extract and essential oil of C. rotundus on memory dysfunction. MATERIALS AND METHODS Cognition was evaluated using the object recognition task that was composed of a square wooden open field box with different shape ob...

Overproduction of interleukin-1 within the brain is associated with Alzheimer's disease and other neurological conditions. We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in...

The onus of caring for patients with dementia mainly falls on the family in Sri Lanka. The traditional closelyknit family structure is changing and it is difficult to find the time and resources to look after the elders. After the diagnosis of dementia, carers need information about the illness and availability of services, emotional support, advice on practical and emotional aspects of caring,...

It is described the case of a 74-years-old woman with probable Alzheimer Disease who showed good clinical response to rivastigmine associated with relevant improvement of cerebral perfusion after 1 year of treatment. The single-photon emission computed tomography (SPECT) scan showed a significant improvement in cortical uptake of the tracer in temporo-parietal and frontal regions in comparison ...

Sleep disturbance in patients with probable Alzheimer’s disease (AD) are frequent and disabling features, affecting approximately 25–60% of all patients. The most common sleep related complaints are insomnia, sleep fragmentation and excessive daytime sleepiness, frequently accompanied by sleep apnea in patients with probable AD.1 Change in sleep precedes the onset of cognitive symptoms in patie...

Dementia associated with probable Alzheimer's disease (AD) is one of the most common types of dementia. Patients with AD often have cholinergic deficits in association with the disease. The cholinesterase inhibitors donepezil hydrochloride, galantamine hydrobromide, and rivastigmine tartrate are the current mainstays of symptomatic treatment for patients with AD. In clinical trials for all thre...

AIM Determine whether patients with Alzheimer's disease demonstrating functional and cognitive decline, following 24-48 weeks of open-label treatment with 9.5 mg/24 h (10 cm(2)) rivastigmine patch, benefit from a dose increase in a double-blind (DB) comparative trial of two patch doses. METHODS Patients meeting prespecified decline criteria were randomized to receive 9.5 or 13.3 mg/24 h (15 c...

Based on the presence of carbamoyl moiety, twenty salicylanilide N,N-disubstituted (thio)carbamates were investigated using Ellman's method for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). O-Aromatic (thio)carbamates exhibited weak to moderate inhibition of both cholinesterases with IC50 values within the range of 1.60 to 311.0 µM. IC50 values for BChE ...

OBJECTIVE To investigate quantitative positron emission tomography (PET) findings and to study whether the cholinergic function differs between respondents to cholinergic medication versus nonrespondents. SETTING Outpatient clinic and university PET imaging center. PARTICIPANTS We studied 17 subjects for more than 1 year after at least moderate traumatic brain injury. Ten of the subjects we...