Freeze-drying is an effective means to control scaffold pore size and preserve its composition. The purpose of the present study was to determine the applicability of lyophilized Platelet-rich fibrin (LPRF) as a scaffold for craniofacial tissue regeneration and to compare its biological effects with commonly used fresh Platelet-rich fibrin (PRF). LPRF caused a 4.8-fold±0.4-fold elevation in Run...

BACKGROUND AND IMPORTANCE The standard clinical technique for repairing peripheral nerve gaps is the use of autologous sensory nerve grafts. The present study tested whether a collagen tube filled with autologous platelet-rich fibrin could induce sensory and motor recovery across a 12-cm nerve gap repaired 3.25 years post trauma, and reduce or eliminate neuropathic pain. CLINICAL PRESENTATION...

Periodontal surgery seeks for tissue regeneration. There is a new grafting material called platelet-rich fibrin (PRF), with multiple properties and one of them is regeneration. This study aimed to assess the regeneration efficacy of Platelet-rich fibrin in periodontal surgery. Were performed several computerized literature searches for randomized controlled trials (RCTs). That evaluated regener...

fibrin glue is used for control of bleeding in various surgical procedures. in this work the ability of fibrin glue to seal punctures in the vascular system is demonstrated. blood samples were taken from rabbits, fibrinogen was separated and fibrin glue was eventually prepared. the rabbits were anesthetized and a midline incision was carried out. the heart and abdominal aorta were exposed. punc...

OBJECTIVE Ovarian and follicle transplantation may preserve fertility in young cancer survivors. In this study, we have transplanted preantral follicles using fibrin gel as a carrier and fibrin gel supplemented with platelet lysate (PL) as a rich source of angiogenic and growth factors. The purpose of this study was to evaluate the role of fibrin gel and PL in follicle transplantation. MATERI...

AMA Utomo Y, Sulistyani LD. Platelet-rich fibrin in combination with mandibular or maxillary non-vascularized bone graft: a systematic review. Journal of Stomatology. 2023;76(2):128-135. doi:10.5114/jos.2023.128819. APA Utomo, Y., & Sulistyani, L. D. (2023). Stomatology, 76(2), 128-135. https://doi.org/10.5114/jos.2023.128819 Chicago Yudy Ardilla, and Lilies D Sulistyani. 2023. "Platelet-rich r...

There has been significant growth and advancement since, the last few decades in use of platelet its derivatives dentistry predominantly oral surgery periodontology. Very little is known about same orthodontics. emerging literature on platelets Platelets being reservoir cytokines factors plays a crucial role various regenerative processes. This review attempts to summarise concerning applicatio...

BACKGROUND For the treatment of the bisphosphonates and other drugs related osteonecrosis of the jaws, currently medication-related osteonecrosis of the jaws (MRONJ), have been established different conservative therapeutic approaches, avoiding surgery except in cases of extreme need. Given the controversy and lack of current consensus regarding MRONJ therapy in patients, new techniques have be...

Recently, by employing intra-vital confocal microscopy, we demonstrated that platelets expose phosphatidylserine (PS) and fibrin accumulate only in the center of the thrombus but not in its periphery. To address the question how exposure of platelet anionic phospholipids is regulated within the thrombus, an in-vitro experiment using diluted platelet-rich plasma was employed, in which the fibrin...

Clinical evidence suggests that individuals with factor VIII (FVIII) deficiency (hemophilia A) are protected against venous thrombosis, but treatment with recombinant proteins can increase their risk for thrombosis. In this study we examined the dynamics of thrombus formation in individuals with hemophilia A and their response to replacement and bypass therapies under venous flow conditions. Fi...