Introduction Uveal melanoma (UM) is the most common primary intraocular malignancy with very poor prognosis. Conventional chemotherapy only rarely prolongs the survival, therefore patients require novel treatment modalities. The discovery of specific receptors for hypothalamic hormones on cancer cells has led to the development of radiolabeled and cytotoxic hormone analogs. Materials and meth...

Download pose: In addition to their expression on pituitary cells, receptors for luteinizing hormone-releasing ne (LH-RH) are found on most prostate cancer cells. These tumoral LH-RH receptors mediate the cytotoxic effects of LH-RH analogs and are potential therapeutic targets. Although pituitary LH-RH ors are downregulated following prolonged exposure to LH-RH agonists, there is no evidence th...

Ambient ionization mass spectrometric imaging of all parts of the seedling of Dysoxylum binectariferum Hook. f (Meliaceae) was performed to reconstruct the molecular distribution of rohitukine (Rh) and related compounds. The species accumulates Rh, a prominent chromone alkaloid, in its seeds, fruits, and stem bark. Rh possesses anti-inflammatory, anti-cancer, and immuno-modulatory properties. D...

A adsorção de íon sulfato em eletrodos de Rh(111), Rh(100) e Rh(110) foi estudada utilizandose a técnica de espectroscopia de FTIR por reflectância in situ. Foi observada somente uma banda vibracional localizada acima de 1200 cm-1 para as três superfícies com baixo índice de Miller e uma banda fraca em 960 cm-1 para o sulfato adsorvido em Rh(111). A banda forte acima de 1200 cm-1 é dependente d...

BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...

Solution NMR spectroscopy of labeled arrestin-1 was used to explore its interactions with dark-state phosphorylated rhodopsin (P-Rh), phosphorylated opsin (P-opsin), unphosphorylated light-activated rhodopsin (Rh*), and phosphorylated light-activated rhodopsin (P-Rh*). Distinct sets of arrestin-1 elements were seen to be engaged by Rh* and inactive P-Rh, which induced conformational changes tha...

To evaluate the relative role of left and right hemispheres (RH) and describe the functional anatomy of RH during ortholinguistic tasks, we re-analyzed the 128 papers of a former left-hemisphere (LH) meta-analysis (Vigneau et al., 2006). Of these, 59 articles reported RH participation, providing 105 RH language contrasts including 218 peaks compared to 728 on the left, a proportion reflecting t...

Surface modification of 600-µm-sized monodisperse gamma-alumina microspheres into magnesium–aluminum spinel, and co-impregnation-based loading Rh–Ni (0.46 wt% Rh, 9.03 Ni) were performed to synthesize catalysts for diesel-steam-reforming hydrogen. The intimate interactions between Rh Ni, the formation alloy, Rh-doping-induced decrease in particle size Ni determined. DFT calculations results rev...