The hardest exposures to indict as health hazards are common ones. Few will worry too much if an obscure dietary practice or a chemical found in only a handful of water supplies is implicated in disease, but the sometimes justified charge that epidemiologists are the “Chicken Littles” of biomedicine— repeatedly telling us that the sky is falling—usually emerges when the phenomenon labeled hazar...

Fatty acid patterns of the serum lipids were measured in 17 children with Reye's syndrome (RS). Serial measurements of total serum free fatty acids (FFA) showed that levels were increased during RS and, after recovery, were significantly lower in the patients who survived. Fatty acid patterns of serum FFA, triglycerides, and phospholipids in patients with RS were significantly different from th...

A case of acute encephalopathy with fatty infiltration of the liver in a child was first described in 1929,1 but the association was not recognised as a clinicopathological entity until 1963.2 The syndrome was quickly recognised in several countries and attracted much clinical and pathological investigation.3-5 A conclusive diagnosis can be made on the findings of a severe acute neurological il...

The accumulation of dicarboxylic acids, particularly long chain, is a prominent feature of Reye's syndrome and diseases of peroxisomal metabolism. We assessed the omega-oxidation of a spectrum of fatty acids in rats and asked whether pretreatment of rats with aspirin, which is known to predispose children to Reye's syndrome, would affect omega-oxidation of long chain fatty acids. We found that ...

OBJECTIVE Based on the assumption that normal TSH concentration rules out the presence of autonomous functioning thyroid nodules (AFTNs), clinical guidelines on the management of thyroid nodules only recommend a thyroid scan if TSH concentration is subnormal. However, the proportion of AFTN presenting with a normal TSH is unknown. Our objective is therefore to determine the proportion of AFTNs ...

Recent studies have indicated that viral infections, aspirin treatment and hyperammonemia are associated with Reye's syndrome. It has also been reported that free fatty acids in serum and total lipids in the liver of Reye's syndrome patients are elevated during illness. The role of the lipid changes in the development of the disorder cannot be optimally studied in human patients, because infect...

In 1993 when Ambros and co-workers [1] discovered that a mysterious Caenorhabditis elegans gene, lin-4, does not encode a protein, but acts in the form of a small RNA and represses the expression of its target gene, lin-14, through base-pairing with its 30 untranslated region (30UTR), nobody would imagine that 20 years later, this category of small RNAs – now widely known as microRNAs (or miRNA...

BACKGROUND Reye's syndrome is characterized by encephalopathy and fatty degeneration of the liver, usually after influenza or varicella. Beginning in 1980, warnings were issued about the use of salicylates in children with those viral infections because of the risk of Reye's syndrome. METHODS To describe the pattern of Reye's syndrome in the United States, characteristics of the patients, and...

The aetiopathogenesis of haemorrhagic shock encephalopathy syndrome (HSES) remains unclear and after concern that a novel environmental agent was the cause, the British Paediatric Association and the Public Health Laboratory Service Communicable Disease Surveillance Centre in 1983 initiated surveillance of this condition in the British Isles. After 1986 cases were ascertained via the British Pa...

Twenty-six children, ages nine-18, who had recovered from Reye's syndrome were tested for possible memory deficits. In reviewing school histories, an unexpected finding was the disproportionately high number of students who were Learning Disabled before contracting Reye's syndrome. Seven of the children had been receiving special education services for being Learning Disabled and another two we...