Oridonin has been utilized for the treatment of various human diseases due to its anti-inflammatory, antibacterial and antitumor effects. However, the precise mechanisms induced by oridonin in human erythroleukemia are yet to be clarified. The present study aimed to elucidate possible oridonin-induced apoptotic mechanisms in OCIM2 cells, as well as the possible mechanisms whereby OCIM2 cells ar...

The objective of this paper is to complement the effluent quality (EQI) and operational cost (OCI) indices used to evaluate (plant-wide) control strategies in wastewater treatment systems with a new dimension dealing with greenhouse gas (GHG) emissions. The GHG evaluation is based on a set of comprehensive dynamic models that estimate the most significant potential on-site (secondary and sludge...

Although case reports suggest the existence of a unique relationship between obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD), results from large-scale epidemiological and clinical studies have been more equivocal. Furthermore, symptom overlap may artificially inflate the significance of the relationship between OCD and PTSD. Utilizing the Obsessive-Compulsive Invent...

In this paper, we describe a method to enhance the FTRAN and BTRAN operations in the revised simplex algorithm by using a reduced basis matrix defined by basic columns and nonbasic rows. This submatrix of the standard basis matrix is potentially much smaller, but may change its dimension dynamically from iteration to iteration. For the classical product form update (“eta update”), the idea has ...

Combined heat and power (CHP) production is an increasingly important energy production technology. CHP production is usually applied in back pressure plants, where the heat and power generation follows a joint characteristic. A CHP system may also comprise separate heat and power production facilities. Cost-efficient operation of a CHP system can be planned using an optimisation model based on...

Targeting Bruton's tyrosine kinase (BTK) with the small molecule BTK inhibitor ibrutinib has significantly improved patient outcomes in several B-cell malignancies, with minimal toxicity. Given the reported expression and constitutive activation of BTK in acute myeloid leukemia (AML) cells, there has been recent interest in investigating the anti-AML activity of ibrutinib. We noted that ibrutin...

The capacity and robustness of cellular MIMO systems is very sensitive to other-cell interference, which will in practice necessitate network level interference reduction strategies [1]– [3]. As an alternative to traditional static frequency reuse patterns, we investigate inter-cell scheduling among neighboring base stations, where adjacent base stations and an (arbitrarily chosen) home base st...

Adenoviruses are efficient gene delivery agents for a variety of neoplasms. In the present study, we have investigated the use of adenoviruses for the delivery of the thymidine kinase (tk) gene into multiple myeloma (MM) cells. We first demonstrated that MM cell lines and MM patient cells express both adenovirus receptors as well as the DF3/MUC1 protein, thus providing a rationale for using ade...

Survivin, a member of the inhibitors-of-apoptosis gene family, is expressed in a cell-cycle-dependent manner in all the most common cancers but not in normal differentiated adult tissues. Survivin expression and regulation were examined in acute myeloid leukemia (AML). Survivin was detected by Western blot analysis in all myeloid leukemia cell lines and in 16 of 18 primary AML samples tested. I...

Histone methylation and demethylation regulate B-cell development, and their deregulation correlates with tumor chemoresistance in diffuse large B-cell lymphoma, limiting cure rates. Since histone methylation status correlates with disease aggressiveness and relapse, we investigated the therapeutic potential of inhibiting histone 3 Lys27 demethylase KDM6B, in vitro, using the small molecule inh...