Abstract A new episode of unrest and phreatic/phreatomagmatic/magmatic eruptions occurred at Ambae volcano, Vanuatu, in 2017–2018. We installed a multi-station seismo-acoustic network consisting seven 3-component broadband seismic stations four 3-element (26–62 m maximum inter-element separation) infrasound arrays during the last phase 2018 eruption episode, capturing least six reported major e...

Hemolytic uremic syndrome (HUS) is a life-threatening infectious disease in childhood for which there is no confirmed therapeutic strategy. Endothelial inflammation leading to microthrombosis formation via complement activation is the main pathology of HUS. Thrombomodulin is an endothelial membrane protein that has anticoagulation and antiinflammatory effects, including the suppression of compl...

INTRODUCTION Recent studies have shown that histones, the chief protein component of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and act as major mediators of the death of an organism. This study was designed to elucidate the cellular and molecular basis of histone-induced lethality and to assess the protective effects of recombin...

BACKGROUND Health care spending is concentrated among a small number of high-cost patients, and the popularity of initiatives to improve care and reduce cost among such "superusers" (SUs) is growing. However, SU costs decline naturally over time, even without intervention, a statistical phenomenon known as regression-to-the-mean (RTM). OBJECTIVES We assess the magnitude of RTM in hospital cos...

Background. Cohort studies have reported that patients improve considerably after individualised homeopathic treatment. However, these results may be biased by regression to the mean (RTM). Objective. To evaluate whether the observed changes in previous cohort studies are due to RTM and to estimate RTM adjusted effects. Methods. SF-36 quality-of-life (QoL) data from a German cohort of 2827 chro...

BACKGROUND The interval from the R wave to the maximum amplitude of the T wave (RTm) contains the heart rate dependency of ventricular repolarization. METHODS AND RESULTS A computer algorithm was developed to quantify the RTm and preceding RR intervals for each of more than 50,000 beats on 24-hour ambulatory electrocardiographic (Holter) recordings to evaluate the dynamic relation between rep...

Individual differences in preschoolers' understanding that human action is caused by internal mental states, or representational theory of mind (RTM), are heritable, as are developmental disorders such as autism in which RTM is particularly impaired. We investigated whether polymorphisms of genes affecting dopamine (DA) utilization and metabolism constitute part of the molecular basis of this h...

BACKGROUND Disseminated intravascular coagulation (DIC) after liver transplantation (LT) is a difficult complication. We report a case of disseminated intravascular coagulation after deceased donor liver transplantation (DDLT) treated with recombinant thrombomodulin (rTM). CASE PRESENTATION A 30-year-old woman underwent right tri-segment split graft DDLT for acute liver failure. She developed...

Finite difference is a simple, fast and effective numerical method for seismic wave modeling, and has been widely used in forward waveform inversion and reverse time migration. However, intensive calculation of three-dimensional seismic forward modeling has been restricting the industrial application of 3D pre-stack reverse time migration and inversion. Aiming at this problem, in this paper, a ...

In physical geodesy, the residual terrain modelling (RTM) technique is frequently used for highfrequency gravity forward modelling. In the RTM technique, a detailed elevation model is high-pass filtered in the topography domain, which is not equivalent to filtering in the gravity domain. This in-equivalence, denoted as spectral filter problem of the RTM technique, gives rise to two imperfection...