objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...

gestational choriocarcinoma usually occurs following an intrauterine pregnancy. we report a case of metastatic choriocarcinoma to the left kidney and lungs with long term intermittent amenorrhea and vaginal bleeding after a normal vaginal delivery. a 43 year old rural woman presented with three years intermittent amenorrhea and vaginal bleeding following normal vaginal delivery. she also compla...

background: choriocarcinoma is a rare highly malignant trophoblastic neoplasm. it can be preceded by any form of gestation including a complete or a partial mole, miscarriage and normal pregnancy. simultaneous intraplacental choriocarcinoma involving both mother and infant is extremely rare. hepatomegaly, anemia, elevated ßhcg is the diagnostic triad. here we report a 6 weeks old afghan girl in...

results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...

myxoid is a common type of liposarcoma. cardiac metastasis of sarcoma is a rare diagnosis. transthoracic echocardiography is a useful tool for beginning the diagnosis. curative resection of metastasis and then combination systemic chemotherapy for advanced disease is recommended. we report a 50 year old woman who presented with a cardiac metastasis of high grade round cell liposarcoma to right ...

introduction laparoscopic surgery is still uncommon for major liver resections. the intrahepatic glissonian approach is a fast and secure way to control the hepatic pedicle. case presentation a patient diagnosed with stenosing sigmoid adenocarcinoma (t3 n1 m+) (n+, positive lymph nodes, m+ positive metastatic desease)with synchronous liver metastases in segments 7 (8 mm), 6-7 (6 cm) and 3 (12 m...

breast metastasis of ovarian carcinoma is rare. to date, only 39 cases have been reported in the english-language  literature  so  far.  we  are  herewith  reporting  a  primary  ovarian  papillary  serous  cyst adenocarcinoma metastasing to breast and epsilateral supraclavicular node in a 58 year old female asthe first case in our centre, located at north-east india.  the purpose of reporting ...

eales' disease is an idiopathic obliterative retinal vasculopathy that is treated with laser photocoagulation, and/or vitrectomy. in order to determine visual outcomes and regression of retinal neovascularization following scattered peripheral retinal photocoagulation, and/or vitrectomy in cases with eales' disease, we did a retrospective study of the records of these patients treated...

introduction : frosted branch angiitis(fba) is a panuveitis with sheating of all retinal vesssels. case presentation : herein we report an immunocompetent person who presented with fever, headache, atypical rash, and hazy vision. ophthalmoscopy of both eyes revealed perivascular sheathing with frosted branch angiitis pattern in veins, patchy retinal hemorrhages. aqueous pcr analysis turned posi...

Introduction: We investigated correlation between the retinal nerve fiber layer (RNFL) thickness and the severity of Parkinson's disease (PD). Methods: In this study, the RNFL thickness of 23 patients with Parkinson’s disease (PD) was compared to normal controls (NCs). PD severity was assessed by the MDS-UPDRS (movement disorder society Unified Parkinson Disea...