The extracellular matrix (ECM) comprises the heterogeneous environment outside of cells in a biological system. The ECM is dynamically organized and regulated, and many biomolecules secreted from cells diffuse throughout the ECM, regulating a variety of cellular processes. Therefore, investigation of the diffusive behaviors of biomolecules in the extracellular environment is critical. In this s...

BACKGROUND Restricted diffusion is the second most common atypical presentation of PRES. This has a very important implication, as lesions with cytotoxic edema may progress to infarction. Several studies suggested the role of DWI in the prediction of development of infarctions in these cases. Other studies, however, suggested that PRES is reversible even with cytotoxic patterns. Our aim was to ...

Pulmonary diffusion capacity for carbon monoxide (DLCO), regional electrical impedance (Z0), and the distribution of technetium-99m-labeled erythrocytes together with concentration of plasma atrial natriuretic peptide (ANP) were determined before and after a 6-min "all-out" row in nine oarsmen and in six control subjects. Two and one-half hours after exercise in the upright seated position, DLC...

TRAP-JENSEN, JENS, AND NIELS A. LASSEN. Restricted d@xsion in skeletal muscle capillaries in man. Am. J. Physiol. 220(2) : 371-376. 197 1 .-The skeletal muscle capillary permeabilities for EDTA51Cr and inulin were measured simultaneously by means of the indicator-diffusion technique in the exercising forearm of nine normal human adults. The capillary permeability data were expressed as the capi...

Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion ...

In this note we present an immersed boundary (IB) method for restricted diffusion with permeable interfaces. These problems arise under a variety of circumstances, e.g., in thermal contact problems [7]. Diffusion in a medium consisting of two regimes separated by permeable boundaries is another example. It is well-known that cell boundaries in a living tissue are permeable to oxygen and water m...

A 35-year-old woman with no previous medical history presented with a 3-day history of progressive left hemisensory loss, ataxia and hemiparesis. On neurological examination she had Medical Research Council (MRC) grade 4 pyramidal weakness, hyper-reflexia and mild incoordination on the left side. Sensory examination revealed decreased light touch, pain, temperature, vibration sense and proprioc...

To cite: Mallio CA, Assenza G, Occhicone F, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013010154 DESCRIPTION A 63-year-old man was admitted owing to the onset upon awakening of anterograde amnesia and spatiotemporal disorientation accompanied by repetitive questioning. No disturbances of consciousness and self-awareness or others focal neurological sy...

BACKGROUND Diffusion-restricted lesions on diffusion-weighted imaging (DWI) are detected in patients with intracerebral hemorrhage (ICH). In this study, we aimed to determine the fate of DWI lesions in ICH patients and whether the presence of DWI lesions is associated with functional outcome in patients with ICH. METHODS This prospective study enrolled 153 patients with acute ICH. Baseline MR...

Introduction: We present a model of simulation of diffusion in white matter. This model has been used in Diffusion Weighted Imaging researches as a tool for employing cylindrically constrained two-tensor models to identify two independent directions within a voxel and assessing the orientation angle as a parameter that influence on fractional anisotropy.   Materials a...