The retinoblastoma susceptibility gene product (RB) is a transcriptional modulator. One of the targets for this modulator effect is the AP-1 binding site within the c-jun and collagenase promoters. The physical interactions between RB and c-Jun were demonstrated by co-immunoprecipitation of these two proteins using anti-c-Jun or anti-RB antisera, glutathione S-transferase affinity matrix bindin...

Business applications composed of heterogeneous distributed components or Web services need mediation to resolve data and process mismatches at runtime. This paper describes mediation in IRS-III, a framework and platform for developing WSMO-based Semantic Web Services. We present our approach to mediation within Semantic Web Services and highlight the role of WSMO mediator types when solving mi...

Business applications composed of heterogeneous distributed components or Web services need mediation to resolve data and process mismatches at runtime. This paper describes mediation in IRS-III, a framework and platform for developing WSMO-based Semantic Web Services. We present our approach to mediation within Semantic Web Services and highlight the role of WSMO mediator types when solving mi...

Estimating the mechanisms that connect explanatory variables with the explained variable, also known as “mediation analysis,” is central to a variety of social science fields, especially psychology, and increasingly fields like epidemiology. Recent work on the statistical methodology behind mediation analysis points to limitations in earlier methods. We implement in Stata computational approach...

Testing multilevel mediation using hierarchical linear modeling (HLM) has gained tremendous popularity in recent years. However, potential confounding in multilevel mediation effect estimates can arise in these models when within-group effects differ from between-group effects. This study summarizes three types of HLM-based multilevel mediation models, and then explains that in two types of the...

The upsurge in mediation activities during the last half-century has given rise to the systematic study offactors determining mediation success. Nevertheless, contemporary theories have only resulted in incomplete explanations of the conditions necessary for successful mediation activities. This essay proposes the creation of a new framework for the evaluation of mediation success, based on the...

Business applications composed of heterogeneous distributed components or Web services need mediation to resolve data and process mismatches at runtime. This paper describes mediation in IRS-III, a framework and platform for developing WSMO-based Semantic Web Services. We present our approach to mediation within Semantic Web Services and highlight the role of WSMO mediator types when solving mi...

The beta type transforming growth factors (TGF-beta) are potent inhibitors of epithelial cell proliferation, and data suggest that growth inhibition by TGF-beta 1 is mediated through suppression of Myc family genes in certain cell types. Indirect evidence has indicated that the product of the retinoblastoma gene (pRb) may also be involved in this pathway. Previously, we have shown that TGF-beta...