There are empirical indications of an isometric scaling relationship between plants' respiratory metabolism rates and nitrogen contents. To test the hypothesis that there may be a similar relationship between plants' respiratory metabolism and phosphorus contents we used data obtained from 150 laboratory and field-grown seedlings representing 30 herbaceous species and 20 woody deciduous species...

Amyothrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of cortical and spinal motoneurons, leading to atrophy of limb, axial, and respiratory muscles. Patients with ALS invariably develop respiratory muscle weakness and most die from pulmonary complications. Overexpression of superoxide dismutase 1 (SOD1) gene mutations in mi...

Hundreds of genes have been associated with respiratory chain disease (RCD), the most common inborn error of metabolism so far. Elimination of the respiratory electron chain by depleting the entire mitochondrial DNA (mtDNA, ρ(0) cells) has therefore one of the most severe impacts on the energy metabolism in eukaryotic cells. In this study, proteomic data sets including the post-translational mo...

The mid Eighteenth Century was a time of great scientific experimentation and observation during which some of the basic aspects of respiratory physiology and metabolism began to be elucidated. This was the time when the fundamental elements of earth, air, fire and water proposed by Aristotle began to be reappraised. The Phlogiston theory was finally exploded and a basic understanding of elemen...

The organization of individual respiratory chain complexes into supercomplexes or respirasomes has attracted great interest because of the implications for cellular energy conversion. Recently, it was reported that commonly used mouse strains harbor a short COX7a2l (SCAFI) gene isoform that supposedly precludes the formation of complex IV-containing supercomplexes. This claim potentially has se...

The anthraquinone emodin has been shown to have antineoplastic properties and a wealth of unconnected effects have been linked to its use, most of which are likely secondary outcomes of the drug treatment. The primary activity of emodin on cells has remained unknown. In the present study we demonstrate dramatic and extensive effects of emodin on the redox state of cells and on mitochondrial hom...

OBJECTIVE The association between energy metabolism and prognosis in polytrauma patients has not yet been defined. The aim of this study was to describe energy metabolism and analyze the prognostic value of respiratory quotient (RQ) and nonprotein respiratory quotient (npRQ) in fasting polytrauma patients (fPP) and polytrauma patients with nutritional support (nsPP). METHODS Twenty-two polytr...

Schistosoma mansoni, one of the causative agents of human schistosomiasis, has a unique antioxidant network that is key to parasite survival and a valuable chemotherapeutic target. The ability to detoxify and tolerate reactive oxygen species increases along S. mansoni development in the vertebrate host, suggesting that adult parasites are more exposed to redox challenges than young stages. Inde...

background the exposure to noxious agwents such as lead my cause lung disorders. objectives in the present study, pulmonary function tests and self-reported respiratory symptoms in lead exposure workers were compared with matched control subjects. materials and methods the frequency of respiratory symptoms were evaluated in a sample of 108 lead exposure workers and 100 control subjects with sim...