introduction in children with nephrotic syndrome, it is probable to determine a hypothyroid state because of thyroxine (t4), tri-iodothyronine (t3) and thyroid-binding globulin loss in presence of proteinuria. objectives: to examine thyroid function in pediatric cases of nephrotic syndrome. methods: in a cross-sectional study, from march 2010 to march 2012, thyroid function tests were performed...

minimal change disease (mcd) is the leading cause of childhood nephrotic syndrome (ns). therefore in pediatrics nephrotic syndrome, most children beyond the first year of life will be treated with corticosteroids without an initial biopsy. children with ns often display a number of calcium homeostasis disturbances causing abnormal bone histology, including hypocalcemia, reduced serum vitamin d ...

The collapsing variant of focal segmental glomerulosclerosis (FSGS) is a renal injury that may be idiopathic or associated with various factors; it is characterized by glomerular collapse, which leads to steroid-resistant nephrotic syndrome (NS) and progressive chronic renal failure. FSGS has not been well studied in children, in which most of the cases are idiopathic. We report six cases of th...

The causes of familial nephrotic syndromes are varied and diverse. Although phenotypic differences are seen with distinct congenital and adult forms, renal pathology tends to be less well defined, with blurring and overlap of diagnoses. Clinically, symptoms of the familial nephrotic syndromes may appear from birth to late in life, which demonstrates the heterogeneity of these diseases. The dise...

most current references recommend divided doses of prednisolone for the initial treatment of idiopathic minimal change nephrotic syndrome in children, with relapse occuring in the majority of them, but there is little experience concerning single-dose prednisolone therapy, especially considering the relapse rate. in this prospective study on 36 consecutive children with primary nephrotic syndro...

Infection in patients with nephrotic syndrome has been described as hallmark of idiopathic nephrotic syndrome. The aim of present article is to study the clinical profile of infections in children with steroid responsive nephrotic syndrome and correlation of serum albumin and serum cholesterol level with episodes of infection in children with steroid responsive nephrotic syndrome. The predictiv...

Introduction AA amyloidosis may develop as a consequence of chronic inflammatory conditions including autoinflammatory diseases(AID). Mevalonate-kinase(MVK) deficiency(MKD) appears to be the least frequent underlying condition among monogenic periodic syndromes. Moreover, amyloidosis rarely manifests during childhood. We report a case of a small child in whom renal biopsy performed because of t...

Abstract Background Nephrotic syndrome is one of the most common chronic kidney diseases in children. Steroid sensitive type constitutes about 90% and steroid resistant 10% total cases. Objectives These national adapted guidelines aim to frame evidence-based recommendations adopted or from IPNA 2020, KDIGO 2021, Japanese 2014 for diagnosis, evaluation, management follow-up nephrotic children (S...

Glomerular disease is a common cause for proteinuria and chronic kidney disease leading to end-stage renal disease requiring dialysis or kidney transplantation in children. Nephrotic syndrome in children is diagnosed by the presence of a triad of proteinuria, hypoalbuminemia, and edema. Minimal change disease is the most common histopathological finding in children and adolescents with nephroti...