Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital...

Methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA), resistant to all antibiotics including Vancomycin, has been reported in Japan, USA, Canada and Brazil. Hence, the main objective of this study was to evaluate the possible presence of Vancomycin resistant or intermediate S.aureus in Karachi. A total of 850 clinical isolates were collected from two civil hospitals in the city betwee...

Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarin have been previously tested for HSV treatment. Three sesquiterpene coumarins [badrakemin acetate (1), kellerin (2) and samarcandin diasteromer (3) ...

ABSTRACT Objectives: to analyze the microbiological profile of leg ulcers patients treated at outpatient clinics and hospitals regarding type microorganism, selection antibiotics, techniques for collection culture material. Methods: literature review performed on LILACS, IBECS, MEDLINE, CINAHL databases, resulting in a descriptive analysis 27 studies. Results: 35.7% studies occurred an care sce...

this paper focuses on a number of american stories which helped educate people and bring about legal or social change. there are many stories which caused major or minor legal and political change, particularly, in the united states. some of them are written by herman melville, harriet beecher stowe, upton sinclair and sidney kingsley. after the publication of white jacket by melville the novel...

SUMMARY During the course of systemic lupus erythematosus in a 10 year-old girl, a go it er develo ped. Subc linical I ly pothyrnic.Jism was found, in addition rising titer of ant imicrosomal antibody and overt hypothyroidism after 6-week cessation of thyroxin tablet lead to the diagnosis of Hashimoto's thyroiditis. Antibodies directed to the thyroid may result in an autoimmune thyroiditis in...

OBJECTIVES Bactericidal activity depends on antibiotic-bacteria couples, resistance phenotype and theoretically on protein binding. This work explores the influence of protein binding on the bactericidal activity of two antibiotics, daptomycin versus vancomycin, that exhibit, respectively, different C(max) (56 versus 25.5 mg/L), protein binding (91.7% versus 36.9%) and thus theoretical free-dru...

Carboxymethyl cellulose (CMC) is considered a non-toxic, biodegradable and biocompatible polymer. CMC-based films are rated as flexible, clear, odorless, moderately tear resistant, resistant to oil grease migration, water soluble. Due its hydrophilicity, CMC can serve matrix encapsulate hydrophobic substances, like essential oils, by emulsion dispersions. The of rue (Ruta graveolens) has antifu...

Drug-resistant tuberculosis, in particular Multi-Drug Resistant (MDR-TB) is an increasing global concern and a major burden for some developing countries, especially the BRICS. It is assumed that every year roughly 350 000 new MDR-TB cases occur in the world, on average in 20.5% of TB patients that have been previously treated but also in 3.5% of persons that have never been on TB treatment bef...

Background and objective: The medicinal effects of flavonoids are widely described in the literature; however, their antimicrobial against antibiotic resistant bacteria yet to be highlighted. This study was aimed at investigating growth biofilm inhibitory taxifolin, a flavonoid, vancomycin-resistant Staphylococcus aureus (VRSA). Methods: Seven VRSA isolates were used assess antibiofilm influenc...