background: tubulin protein being the fundamental unit of microtubules is actively involved in cell division thus making them a potential anti-cancer drug target. in spite of many reported drugs against tubulin, few of them have started developing resistance in human β-tubulin due to amino acid substitutions. methods: in this study we generated three mutants (f270v, a364t and q292e) using model...

INTRODUCTION Extracorporeal circulation (EC) is very important in cardiac surgery but causes significant damage to the blood, including hemolysis. OBJECTIVE To quantify the rate of hemolysis at different times during EC in elective coronary artery bypass grafting. METHODS We measured rates of hemolysis of 22 patients at 6 different times during myocardial revascularization during EC: T0 - b...

Computed tomography was used to determine the vertical gradient of physical density in peripheral lung tissue of 12 healthy supine subjects, at total lung capacity and residual volume. At total lung capacity the mean (SD) density of peripheral lung tissue at the level of the mid right atrium was 0.0715 (0.017) g/cm3 and the vertical gradient of density was slight. At residual volume the density...

INTRODUCTION Thixotropy is a passive property of the skeletal muscle that depends on the muscle's immediate history of contraction and length change. Inspiratory-muscle thixotropy affects the end-expiratory position of the rib cage in normal subjects. OBJECTIVE To determine whether a reduction in end-expiratory chest-wall volume occurs after thixotropy conditioning of inspiratory muscles in p...

In patients with chronic renal failure on hemodialysis, left ventricular hypertrophy is related to the increase in total peripheral vascular resistance and volume overload. The presence of residual diuresis enables greater control of the volemia of these. We evaluated the morpho-functional changes of the left ventricle in patients with chronic kidney disease on hemodyalisis treatment with and w...

OBJECTIVE For optimal imaging in first-pass radionuclide angiography (FPRNA) studies, 1.11 GBq (30 mCi) 99mTc-sestamibi doses are drawn up in volumes of 0.1-0.3 mL. A single bolus injection of this small volume is important to obtain accurate time-activity curves. Because of the small volume and concentrated radioactivity, it is undesirable for study effectiveness and image quality to have a si...

Objective To perform a quantitative computed tomography (CT) assessment of short- and long-term outcomes of autologous fat injection augmentation in patients with unilateral vocal fold paralysis. Study Design Retrospective case series. Methods Twelve patients who had undergone autologous fat injection augmentation for unilateral vocal fold paralysis in our hospital between 2011 and 2015 wer...

The morbidly obese are known to have impaired respiratory function. A prospective study of the changes in lung volumes, carbon monoxide transfer, and arterial blood gas tensions was undertaken in 29 morbidly obese patients before and after surgery to induce weight loss. Before surgery the predominant abnormality in respiratory function was a reduction in lung volumes. These increased towards no...

Background: Creating a socket with proper fit is an important factor to ensure the comfort and control of prosthetic devices. Several techniques are commonly used to cast transtibial stumps but their effect on stump shape deformation is not well understood. This study compares the dimensions, circumferences and volumes of the positive casts and also the socket comfort between two casting method...

Bake, B. and Grimby, G. (1974). Thorax, 29, 366-370. Regional ventilation and gas exchange after hemicorporectomy. Maximum expiratory flow volume curves, gas exchange, closing volume, and regional distribution of lung volumes and ventilation were measured in a young man after hemicorporectomy. The patient breathed at low lung volume, close to residual volume, and his total lung capacity was 63%...