Auditory brainstem response (ABR) reflects activation of the neural generators along the ascending auditory pathway when a sound is heard. In this study, we explored the relationship between brainstem encoding of click and speech signals in normal-learning children and in those with language-based learning problems. To that end, ABR was recorded from both types of stimuli. We found that the nor...

The false negative rate of the auditory brainstem response (ABR) for the detection of vestibular schwannoma (VS; acoustic neuroma) has been reported to range from 2 to 9 percent. The introduction of magnetic resonance with gadolinium contrast (Gd MRI) may be expected to raise the false negative rate, because smaller tumors can now be detected. We present two cases that illustrate some of the co...

The auditory brainstem response (ABR) was recorded in adult budgerigars (Melopsittacus undulatus) in response to clicks and tones. The typical budgerigar ABR waveform showed two prominent peaks occurring within 4 ms of the stimulus onset. As sound-pressure levels increased, ABR peak latency decreased, and peak amplitude increased for all waves while interwave interval remained relatively consta...

The effects of notch width of notch masking noise on the auditory brainstem response (ABR) were investigated with ten normal-hearing subjects. Wave V latencies and amplitudes were measured to a click in quiet and in the presence of noise with notches centered around 1000 Hz and 4000 Hz. Notch width was either 0.5, 1.0, 1.5, 2.0, or 2.5 octaves. A 95 dB SPL broadband noise was necessary to mask ...

OBJECTIVE Vestibular migraine (VM) is a clinical condition characterized by temporal overlap between vestibular symptoms and migraine. In this study, we aimed to determine the changes in vestibular myogenic potential (cVEMP) and auditory brainstem response (ABR) in patients with VM and migraine. MATERIALS AND METHODS A total of 86 participants with no hearing loss or additional disease betwee...

Brainstem frequency-following responses (FFRs) probe the neural transcription of speech/music, auditory disorders, and plasticity in subcortical auditory function. Despite clinical and empirical interest, the response's neural basis remains poorly understood. The current study aimed to more fully characterize functional properties of the human FFR (topography, source locations, generation). Spe...

Enzyme replacement therapy (ERT) has improved the quality of life in patients with Gaucher disease (GD). An emerging concern is whether ERT can also halt the neurologic progression in type 3 GD. The authors examined the auditory brainstem response (ABR) in eight children with type 3 GD undergoing high-dose ERT and found a consistent deterioration in ABR response. They conclude that ERT does not...

Background. Developing interventions to improve medication adherence may depend upon discovery of novel behavioral risk factors for nonadherence. Objective. Explore the effects of emotional response (ER) on adherence to antihypertensive medication and on systolic blood pressure (SBP) improvement. Design. We studied 101 adults with diabetes and hypertension. The primary outcome, 90-day "percenta...

We introduce a new approach, the cross-phaseogram, that captures the brain's ability to discriminate between spectrotemporally dynamic speech sounds, such as stop consonants. The goal was to develop an analysis technique for auditory brainstem responses (ABRs) that taps into the sub-millisecond temporal precision of the response but does not rely on subjective identification of individual respo...