objective(s):leptin receptor (lepr) is a member of the class i cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. we have investigated the effect of q223r polymorphism on the breast cancer susceptibly in a sample of iranian subjects. materials and methods:we utilized a polymerase chain reaction (pcr) restriction fragment length polymorphi...

Arzu, felsefeden psikolojiye, maddi kültür çalışmalarından sanat çalışmalarına kadar uzanan geniş bir alanda incelenen, üzerinde düşünülen olgudur. Edebiyat sahasında da incelenen arzu, özne-nesne ilişkisine dayalı anlatı türlerinde özneyi harekete geçiren itici güç işleviyle anlatının unsuru hâline gelir. Sözlü kültürden modern romana geleneğinin merkezinde yer alan bu güç, kahramanı arayışa, ...

In this paper, we propose a refinement of the modelling of biological regulatory networks based on the discrete approach of Rene Thomas. We refine and automatise the use of delays of activation/inhibition in order to specify which variable is more quickly affected by a change of its regulators. The formalism of linear hybrid automata is well suited to allow such refinement. We then use HyTech f...

The so-called leapfrog transformation that was first introduced for fullerenes (trivalent polyhedra with 12 pentagonal faces and all other faces hexagonal) is generalised to general polyhedra and maps on surfaces. All spherical polyhedra can be classified according to the i r leapfrog order. A polyhedron is said to be of Clar type if there exists a set of faces that cover each vertex exactly on...

Gary Thorgaard a *, George Bailey , David Williams , Donald Buhler , Stephen Kaattari , Sandra Ristow , John Hansen , James Winton , Jerri Bartholomew , James Nagler , Patrick Walsh , Matt Vijayan , Robert Devlin , Ronald Hardy , Kenneth Overturf , William Young , Barrie Robison , Caird Rexroad III , Yniv Palti p , Bernie May, Scott LaPatra, Ruth Phillips, Linda Park, Takashi Sakamoto, Nobuaki ...

The rote of prostaglandin endoperoxide synthetase in thà ̈ in vìvo activation of benzo(a)py rene to reactive metabolites capable of interacting irreversibly with cellular macromolecules was stud ied in guinea pig liver, lung, kidney, spleen, small intestine, colon, and brain. DNA and protein covalent binding experiments were made after systemic administration of acetylsalicylic acid (200 mg/kg)...

properties. In these studies a large number of solvents were employed for the administration of 3,4-benzpy rene. The solutions of the hydrocarbon were in stilled into the stomachs of mice and cats and the rate of the absorption of the fluorescent carcinogen determined directly in the wall of the stomach in the manner described in the first paper of this series (7). The intensity of fluorescence...

Anton J. Bilchik, John Wayne Cancer Institute at St John’s Health Center, Santa Monica, CA Graeme Poston, Royal Liverpool and Aintree University Hospitals, Liverpool, UK Steven A. Curley, The University of Texas M.D. Anderson Cancer Center, Houston, TX Steven Strasberg, Siteman Cancer Center at Washington University in St Louis, St Louis, MO Leonard Saltz, Memorial Sloan Kettering Cancer Center...