The SCAR/WAVE complex drives the actin polymerisation that underlies protrusion of the front of the cell and thus drives migration. However, it is not understood how the activity of SCAR/WAVE is regulated to generate the infinite range of cellular shape changes observed during cell motility. What are the relative roles of the subunits of the SCAR/WAVE complex? What signaling molecules do they i...

Structural and molecular changes in the guinea pig organ of Corti were studied using histochemistry and electron microscopy in the course of drug-induced hair cell degeneration. Actin filaments disappear from the cuticular plate and the stereocilia. An actin-rich bridge appears in the apical region of dying hair cells. Two supporting cells form a scar for a given hair cell. The supporting cells...

introduction : open rhinoplasty is very common now a days and the number of candidate for this type of surgery are increasing. this research was conducted regarding to the prevalence of rhinoplasty surgery , the importance of the residual scar analyze including columellar scar after surgery, different results caused by the effect of incision type in this surgery and lack of enough data and expe...

BACKGROUND Mismatch between myocardial innervation and perfusion assessed with positron emission tomography (PET) is a potential risk marker for ventricular arrhythmias in patients with ischemic cardiomyopathy. This mismatch zone originates from residual viable myocardium that has sustained ischemic nerve injury. Heterogenic scar size assessed with late gadolinium-enhanced (LGE) cardiac magneti...

Closure of donor site of the flap has special problems. Reduction of this site will decrease the morbidity of operation. In this study, we present our experience in donor site size reduction. METHODS Between 2006 and 2008, 15 patients with skin and soft tissue defects underwent operation. In all patients, coverage of defect was performed with various flaps. Substratum horizontal mat-tress sut...

introduction:  the aim of this study was to compare the preventive effects of corticosteroids and curcumin on subglottic stenosis in an animal model.  materials and methods: twenty-one male german shepherd dogs were used for this study. after standardized trauma to the subglottic area, the dogs were divided into three groups. group a received curcumin (450 mg/ day) for 15 days; group b received...

abstract a32 year-old multigravid patient with 10 weeks of pregnancy was referred to the emergency ward with massive vaginal bleeding and preshock state. suction curettage, laparotomy, uterine artery ligation, macdonald cerclage, and hysterectomy was done, in that order. after hysterectomy and massive transfusion she recovered. when a diagnosis of cesarean scar pregnancy is made in the emergenc...

background gigantomastia is a rare condition characterized by excessive breast growth and can be physically and psychosocially disabling for the patient. regarding management of gigantomastia, this study evaluates the outcomes of superomedial pedicle with vertical scar or wise pattern skin excision. methods a total of 425 patients who underwent reduction mammoplasty in our institution were revi...

primary choriocarcinoma of the uterine cervix is an extremely rare disease. the clinical diagnosis of cervical choriocarcinoma is difficult, because of its rarity and being non-specific abnormal vaginal bleeding the most common symptom. in the present report,the authors present a case of cervical choriocarcinoma, which was initially misdiagnosed as a cesarean section scar ectopic pregnancy. rem...

background: replacement of the lost tissue is the major concerns of the plastic surgeons. expanded area should be coherent with the surrounding tissue. tissue expansion technique is the reforming methods the skin tissue scarcities. several methods for tissue expansion are available; including usage of silicon balloon and injecting fluid into the tissue expander. materials and methods: in a clin...