BACKGROUND AND OBJECTIVES An early histopathologic predictor of the renal prognosis, before the occurrence of advanced glomerular sclerosis/interstitial fibrosis and/or apparent renal dysfunction, remains to be established in IgA nephropathy (IgAN). This study aimed to determine whether the glomerular density (GD; nonsclerotic glomerular number per renal cortical area) of biopsy specimens obtai...

BACKGROUND AND OBJECTIVES The United States Renal Data System (USRDS) is a commonly utilized database for epidemiologic research of ESRD patients. USRDS uses Medical Evidence Form 2728 to collect medical information about ESRD patients. The validity of the Form 2728 "primary cause of renal failure" field for glomerular diseases has not been evaluated, although inconsistencies between Form 2728 ...

BACKGROUND Although percutaneous renal biopsy remains an essential tool in the diagnosis and treatment of renal diseases, in recent times the traditional procedure of nephrologists has been performed by non-nephrologists rather than nephrologists at many institutions. The present study assessed the safety and adequacy of tissue yield during percutaneous renal biopsy according to practitioners a...

OBJECTIVE  To determine the pattern of histopathology in living-related, kidney transplant recipients (KTRs) from a centre Khyber Pakhtunkhwa (KPK), Pakistan. STUDY DESIGN Descriptive, observational study. PLACE AND DURATION OF Institute Kidney Diseases, Peshawar, August 2008 to July 2018. METHODOLOGY A retrospective review graft biopsy reports and clinical charts was carried out. Allograft bio...

This chapter begins with a very brief history of renal pathology, discusses the role of the renal biopsy in the care of patients with kidney disease, and presents basic concepts of pathologic evaluation of kidney diseases. The emphasis in this chapter is on the pathologic evaluation of native kidney lesions in real biopsy specimens, and thus is most relevant to the medical renal diseases covere...

BACKGROUND Fabry Disease (FD) is a genetic disorder caused by alpha-galactosidase A deficiency. Certain drugs, such as hydroxychloroquine, can produce renal deposits that mimic morphological findings seen in FD, characterizing a type of drug-induced renal phospholipidosis. CASE PRESENTATION Case 1: A 28-year-old female patient with systemic lupus erythematosus who had been using hydroxychloro...

BACKGROUND Type 2 diabetes mellitus (T2DM) is reportedly the leading cause of end-stage renal disease (ESRD) worldwide. However, non-diabetic renal diseases (NDRD) are not uncommon among T2DM patients with renal involvement. Our study aimed to examine the prevalence of NDRD in T2DM and clinical markers for diabetic nephropathy (DN) and NDRD and to determine the role of renal biopsy in T2DM pati...

A renal biopsy was performed in a 47-year-old man with haemophilia A. Thirty minutes after administration of an intravenous bolus of 4000 units of recombinant factor VIII, which increased the activity to 74-91%, a needle renal biopsy was successfully performed, followed by administration of 3000 units of factor VIII in the evening, and then the subsequent morning and evening. The patient was di...

BACKGROUND Renal allograft recipients can be monitored for polyomavirus-associated nephropathy (PVAN) using urine samples. Because virus in urine can be derived from the kidneys, ureter, or urinary bladder, we evaluated whether measurement of intrarenal concentrations of viral DNA might serve as a more reliable monitoring tool. METHODS Real-time quantitative polymerase chain reaction was used...