نتایج جستجو برای: relaxivity
تعداد نتایج: 880 فیلتر نتایج به سال:
Purpose: Higher doses of gadolinium-based contrast agents (GBCA) are often used for contrast-enhanced MRA (CE-MRA). Patients with moderateto-severe (stages 3-5) chronic kidney disease undergoing contrast-enhanced MR imaging are known to be at increased risk for developing nephrogenic systemic fibrosis, particularly with higher doses or repeated exposure to GBCA (1-2). Herein we review informati...
In recent years, numerous reports concerning the reduced relaxivity of cell-internalized contrast agents (CA) have been made (e.g. [1], [2]). This reduction is caused by the compartmentalization of CA inside the cells and has already been thoroughly investigated [3]. The aim of this study was to develop a method to correctly quantify the density of cell populations with intracellular CA despite...
H NMR of two H2@C60 nitroxide derivatives has been characterized indirectly by reducing to their corresponding hydroxylamines. Nuclear spin relaxation of the endohedral H2 and external protons of the H2@C60 nitroxide and its corresponding hydroxylamine were measured and analyzed. The observed spectra are consistent with negligible scalar coupling between the unpaired electron and the endo-H2. A...
We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular (1)H water relaxivity (r(1)) is ca. 5 mM(-1) s(-1). The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provi...
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