In this paper we consider a second order, Sturm-Liouville-type boundary-value operator of the form Lu := −[pu∇]∆ + qu, on an arbitrary, bounded time-scale T, for suitable functions p, q, together with suitable boundary conditions. We show that, with a suitable choice of domain, this operator can be formulated in the Hilbert space L(Tκ), in such a way that the resulting operator is self-adjoint,...