The NAD(+)-dependent deacetylases, namely sirtuins, are involved in the regulation of a variety of biological processes such as gene silencing, DNA repair, longevity, metabolism, apoptosis, and development. An enzyme from the parasite Leishmania infantum that belongs to this family, LiSIR2RP1, is a NAD(+)-dependent tubulin deacetylase and an ADP-ribosyltransferase. This enzyme's involvement in ...

Introduction Burns are a major global public health problem. It is estimated that over 300 million burn victims die each year worldwide. Most accidents are domestic or on workplace and involve mainly women and children. With the advances made in the care of burned patients, the mortality has decreased in recent years and the inhalation injury has become the leading cause of death in these patie...

Low-density lipoprotein receptor-related protein-1 (LRP1) plays multifunctional roles in lipid homeostasis, signaling transduction, and endocytosis. It has been recognized as an endocytic receptor for many ligands and is involved in the signaling pathways of many growth factors or cytokines. Dysregulation of LRP1-dependent signaling events contributes to the development of pathophysiologic proc...

Although the authors state three times throughout their paper that TRP-1 is a variant of the previously described TMX-2/CGI-31 protein they do not provide any DNA or protein sequence comparison to illustrate the degree of homology between both variants. When attempting to perform this comparison myself I found that TRP-1 DNA or protein sequences are not available at GenBank and two email reques...

conclusions these findings suggest that apelin does not play any significant role in regulating the pain threshold in type 1 diabetes mellitus during exercise training. results plasma apelin level was higher (0.3 vs. 0.1, p < 0.0001) and the tail-flick latency was lower (2.2 vs. 3.8, p < 0.0001) in the d group than in the nd group. after the training program, plasma apelin levels decreased in t...

background brucellosis is an important cosmopolitan infection disease caused by organisms belonging to the genus brucella. the cgt gene (cyclic β-1, 2 glucan transporter gene) is a virulent factor in brucella genus. the present study was conducted with the aim of cloning and expression of brucella cgt gene. materials and methods brucella melitensis cgt gene was amplified from extracted chromoso...

abstract       background and objectives: plasmodium falciparum merozoite surface protein-1 (pfmsp-1) is a promising vaccine against malaria during its blood stages which play an important role in immunity to this disease. polymorphic nature of this gene is a major obstacle in making an effective vaccine against malaria. in this study, the genetic diversity of plasmodium falciparum isolates was...

in this study, in order to facilitate and accelerate the production of eukaryotic protein alpha 1-antitrypsin (aat) with correct post-translational modifications, a protein production system based on the transduction of cho and cos-7 cells using lentiviral vectors was developed. human aat cdna was cloned into a replication-defective lentiviral vector. the transgene aat-jred chimer was transferr...

conclusions this case showed the effect of additional anakinra on children with fmf who were colchicine resistant. case presentation herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of fmf. she had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. addition of recombinant interleukin-1 receptor...

background : ruptured cerebral aneurysms (icas) are the most common non-traumatic cause of subarachnoid hemorrhage (sah) that is associated with life threatening complications such as vasospasm, infarction, and hydrocephalus (hcp). the active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with monocyte chemoattractantprote...