Osteonecrosis of the jaw is usually a potential complication of bisphosphonate therapy. In a cancer patient, this disease entity can be misdiagnosed as a metastatic lesion. Our aim is to make clinicians aware of bisphosphonate associated osteonecrosis of the jaw to prevent misdiagnosis and initiate proper treatment at the earliest. We present the case of a breast cancer patient with multiple bo...

RELATED TO THE SUBJECTS OF THE THESIS IV. A Janovszky, R Varga, A Szabó, D Garab, M Boros, J Piffkó. Microcirculatory consequences of chronic bisphosphonate treatment after tooth extraction in a rat model. Int J Oral Maxillo Surg. 2013;42:(11)1187.

Mandibular fracture is usually the clinical end of bisphosphonate-related osteonecrosis of the jaw. This is a painful complication and patients cannot feed as usual, with a worsening of their quality of life. The goal of treatment in bisphosphonate related osteonecrosis of jaw (BRONJ) patients is to slow progression of bone necrosis. We present a novel technique for treatment of severe mandibul...

We report a rare case of osteonecrosis of the jaw following necrotizing gingivitis in a Japanese AIDS patient. Intraoral examination showed exposed necrotic bone in the left mandible and spontaneous loss of teeth. This patient was successfully treated with highly active anti-retroviral therapy combined with minimally invasive surgical procedures to remove the osteonecrosis of the jaw.

Recent studies have been reported that angiogenesis suppression may play a role in developing bisphosphonate-related osteonecrosis of the jaw (B-ONJ). According to these evidence we evaluated the role of VEGF as predictive marker of B-ONJ onset. Of the 81 patients, 6 developed B-ONJ following bisphosphonate treatment. These patients showed a strongest decrease in VEGF circulating levels at day ...

Background. Antiresorptive drug-related osteonecrosis of the jaw (ADRONJ) is a serious complication cancer patients or osteoporosis, under treatment with antiresorptive drugs. At present, there no scientific evidence consensus on most appropriate approach depending stages ADRONJ. Objective. To assess effectiveness different therapeutic options in Search methods. The following electronic databas...