We read with the great interest the recent publication on a second trigeminal CGRP receptor by Walker et al. The authors convincingly present the presence of a functional noncanonical CGRP receptor (AMY1) at neuronal sites in the trigeminal system. The presence of a second CGRP receptor has been debated and although it is not yet recognized by IUPHAR, several reports have previously suggested t...

Oxidative stress may play a role in the pathogenesis of age-related macular degeneration (AMD). In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C> T, rs1800566), NOS3 (894G>T, rs1799983) and NFE2L2 (28312647A>G, rs6726395). We found that the G/G genotype of the rs67...

Psychosocial and pharmacological treatments for cocaine abuse are associated with high rates of attrition (e.g., Gawin et al. 1989; Higgins et al. 1993; Kang et al. 1991; Weddington et al. 1991). This is particularly unfortunate because poor drug abuse treatment retention is associated with poor outcomes. For example, several studies report that longer treatment duration predicts improved outco...

The effectiveness of substance abuse treatment programs can be monitored by self-reported drug use and objectively measured by qualitative and quantitative urinalysis. The advantages and disadvantages of each of these three methods of assessing drug use are reviewed. Data collected in a clinical trial of a behavioral treatment for cocaine abuse are used to evaluate the relationships among quali...

of Thesis Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Master of Science DISSOCIATING COMPONENTS OF COGNITIVE CONTROL USING HIGHDENSITY EVENT-RELATED POTENTIALS: IMPLEMENTATION OF CONTROL, CONFLICT PROCESSING, AND ERROR MONITORING By Michael James Larson May 2004 Chair: William M. Perlstein Major Department: Clinical ...

The most recent update to the American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) included Internet Gaming Disorder as a new potential psychiatric condition that merited further scientific study. The present research was conducted in response to the APA Substance-Related Disorders Working Group's research call to estimate the extent to which mi...

Several authors have suggested that chaos theory, the study of nonlinear dynamics and the application of the knowledge gained to natural and social phenomena, might yield insight into substance-related disorders. In this article, we examine the dynamics of substance abuse by fitting a nonlinear model to a time series of the amount of alcohol, which an adult male with a diagnosis of substance ab...

Obsessive-compulsive and related disorders in ICD-11 Dan J. Stein, Leonardo F. Fontenelle, Geoffrey M. Reed Department of Psychiatry, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa. Institute of Psychiatry, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Instituto D’Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil. 4 School of Psychologica...

INTRODUCTION: Telcagepant (MK-0974) is a novel, orally active and selective CGRP receptor antagonist being investigated for acute treatment of migraine. Early clinical data suggested greater than dose proportional increases in exposure following oral administration. The aim of the present studies was to definitively characterize the oral and IV dose proportionality of telcagepant. METHODS: Heal...

Results: Of the 109 suicide deaths identified by the coroner at the time of the study, we were able to investigate 102. At time of death, 65% of the suicide victims had a mood disorder, 59% had a substance-related disorder, and 42% had concurrent mood and substance-related disorders. The lifetime prevalence of substance-related disorders among these suicide victims was 66%. Finally, 52% of the ...