In recent years, Platelet Rich Plasma (PRP) and Adipose-Derived Stem Cells (ADSCs) have been used separately for many clinical applications, especially skin rejuvenation. A combined injection of PRP and ADSCs could therefore be used to treat skin wrinkles. However, there are controversies and reports with conflicting results regarding the efficacy of this treatment. The authors aimed to determi...

High power lasers are used extensively in medicine while lower power applications are popular for optical imaging, optogenetics, skin rejuvenation and a therapeutic modality termed photobiomodulation (PBM). This study addresses the therapeutic dose limits, biological safety and molecular pathway of near-infrared (NIR) laser phototoxicity. Increased erythema and tissue damage were noted in mice ...

Treatment of human promonocytic leukemic cell line U937 with mild hyperthermia in the temperature range of 40-43°C resulted in differentiation of these cells into monocyte/macrophage-like cells in a heat dose and time dependent manner. This process was accompanied by marked morphological, functional and proliferational changes. U937 cells which normally grow in supension in the logarithmic...

A number of recent studies have reported the phenomenon of “software aging”, characterized by progressive performance degradation and/or an increased occurrence rate of hang/crash failures of a software system due to the exhaustion of operating system resources or the accumulation of errors. To counteract this phenomenon, a proactive technique called “software rejuvenation” has been proposed. I...

Rebooting is one of the commonly used approaches to recover from undesired crash or performance degradation in software systems. Recently, however, planned and periodic restart or rejuvenation has been proposed as a reliability management tool for avoiding unwanted failure of long-running systems. This paper presents an interesting observation that periodic rejuvenation alters the lifetime dist...

Generalized Renewal Processes are useful for approaching the rejuvenation of dynamical systems resulting from planned or unplanned interventions. We present new perspectives for the Generalized Renewal Processes in general and for the Weibull-based Generalized Renewal Processes in particular. Disregarding from literature, we present a mixed Generalized Renewal Processes approach involving Kijim...